The functional analyses of Angptl2 in diabetic eye complication

Research Project

Project/Area Number	25462720
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Ophthalmology
Research Institution	Kumamoto University
Principal Investigator	Ito Yasuhiro 熊本大学, 医学部附属病院, 助教 (70380996)
Co-Investigator(Kenkyū-buntansha)	FUKUSHIMA MIKIKO 熊本大学, 医学部附属病院, 准教授 (10284770) 谷原秀信熊本大学, 大学院生命科学研究部, 教授 (60217148)
Co-Investigator(Renkei-kenkyūsha)	TANIHARA HIDENOBU 熊本大学, 医学部附属病院, 教授 (60217148)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000) Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	糖尿病網膜症
Outline of Final Research Achievements	Concentration of Angptl2 in vitreous of patients with diabetic macular edema was increased compared to the control, and Angptl2 expression was found in inner limiting membrane of those patients. Moreover, IL-6, MCP-1 and ICAM-1 expression was decreased in streptozotocin-induced diabetic Angptl2 knockout mice compared to the control, and leukocyte adhesion to endothelial cells was suppressed in diabetic Angptl2 knockout mice. Those findings suggest that Angptl2 may play a role in pathological condition of diabetic retinopathy.