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The functional analyses of Angptl2 in diabetic eye complication

Research Project

Project/Area Number 25462720
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionKumamoto University

Principal Investigator

Ito Yasuhiro  熊本大学, 医学部附属病院, 助教 (70380996)

Co-Investigator(Kenkyū-buntansha) FUKUSHIMA MIKIKO  熊本大学, 医学部附属病院, 准教授 (10284770)
谷原 秀信  熊本大学, 大学院生命科学研究部, 教授 (60217148)
Co-Investigator(Renkei-kenkyūsha) TANIHARA HIDENOBU  熊本大学, 医学部附属病院, 教授 (60217148)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords糖尿病網膜症
Outline of Final Research Achievements

Concentration of Angptl2 in vitreous of patients with diabetic macular edema was increased compared to the control, and Angptl2 expression was found in inner limiting membrane of those patients. Moreover, IL-6, MCP-1 and ICAM-1 expression was decreased in streptozotocin-induced diabetic Angptl2 knockout mice compared to the control, and leukocyte adhesion to endothelial cells was suppressed in diabetic Angptl2 knockout mice. Those findings suggest that Angptl2 may play a role in pathological condition of diabetic retinopathy.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (2 results)

All 2015 2013

All Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] Microglial cells are associated with pathogenesis of proliferative diabetic retinopathy2015

    • Author(s)
      Yasuhiro Ito, Mikiko Fukushima, Hidenobu Tanihara
    • Organizer
      15th EURETINA Congress
    • Place of Presentation
      ニース、フランス
    • Year and Date
      2015-09-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Angiopoietin-like protein 2 contributes to pathogenesis of diabetic retinopathy2013

    • Author(s)
      伊藤康裕
    • Organizer
      European Association for Vision and Eye Research
    • Place of Presentation
      ニース、フランス
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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