Research of epithelial-to-mesenchymal transition via redox regulation for age related macular degeneration

Research Project

Project/Area Number	25462721
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Ophthalmology
Research Institution	Kumamoto University
Principal Investigator	Inomata Yasuya 熊本大学, 医学部附属病院, 助教 (50452884)
Co-Investigator(Kenkyū-buntansha)	Kawaji Takahiro 熊本大学, 医学部附属病院, 講師 (30423677) 高橋枝里熊本大学, その他の研究科, 助教 (60622602)
Co-Investigator(Renkei-kenkyūsha)	Takahashi Eri 熊本大学, 大学院生命科学研究部, 助教 (60622602)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000) Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	網膜色素上皮 / 上皮間葉転換 / 加齢黄斑変性
Outline of Final Research Achievements	Our results demonstrated that merlin exerts inhibitory effects on TNF-α-induced EMT by regulating hyaluronan endocytosis and the TAK1-p38MAPK signaling pathway. The proliferative and mesenchymal characteristics of RPE cells play important roles in the development of intraocular fibrotic disorders.