Research of epithelial-to-mesenchymal transition via redox regulation for age related macular degeneration
| Project/Area Number |
25462721
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kumamoto University |
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Principal Investigator |
Inomata Yasuya 熊本大学, 医学部附属病院, 助教 (50452884)
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| Co-Investigator(Kenkyū-buntansha) |
Kawaji Takahiro 熊本大学, 医学部附属病院, 講師 (30423677)
高橋 枝里 熊本大学, その他の研究科, 助教 (60622602)
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| Co-Investigator(Renkei-kenkyūsha) |
Takahashi Eri 熊本大学, 大学院生命科学研究部, 助教 (60622602)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 網膜色素上皮 / 上皮間葉転換 / 加齢黄斑変性 |
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| Outline of Final Research Achievements |
Our results demonstrated that merlin exerts inhibitory effects on TNF-α-induced EMT by regulating hyaluronan endocytosis and the TAK1-p38MAPK signaling pathway. The proliferative and mesenchymal characteristics of RPE cells play important roles in the development of intraocular fibrotic disorders.
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Report
(4 results)
Research Products
(2 results)
