The inhibition of fibronectin ED-A suppresses the development of proliferative vutreoretinopathy

• Project/Area Number: 25462722
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Oita University
• Principal Investigator: KIMOTO KENICHI 大分大学, 医学部, 准教授 (50315339)
• Co-Investigator(Kenkyū-buntansha): 久保田 敏昭 大分大学, 医学部, 教授 (30205140) ; 山田 喜三郎 大分大学, 医学部, 講師 (50452909)
• Research Collaborator: YOKOYAMA Katsuhiko
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 増殖硝子体網膜症 / TGF-β2 / 網膜色素上皮細胞 / 細胞外マトリックス / fibronectin ED-A / 網膜色素上皮 / TGF-β / Fibronectin ED-A / 増殖性硝子体網膜症 / Smad / p38MAPK / Rho-kinase / PI3K

Outline of Final Research Achievements

TGF-β2 induces epithelial mesenchymal transition (EMT) in retinal pigment epithelium (RPE). Therefore, it has been implicated as the key mediator of proliferative vitreoretinopathy. Type I collagen and fibronectin ED-A production were activated by TGF-β2 in RPE. Anti-fibronectin ED-A antibody inhibited TGF-β2-induced type I collagen mRNA expression and type I collagen synthesis. Fibronectin ED-A may be a new therapeutic target for treating proliferative vitreoretinopathy.

Research Products

• [Journal Article] Foveal hypoplasia in patients with stickler syndrome. (2017)
  • Author(s): Matsushita I, Nagata T, Hayashi T, Kimoto K, Kubota T, Ohji M, Kusaka S, Kondo H.
  • Journal Title: Ophthalmology Volume: 印刷中
  • Peer Reviewed / Open Access
• [Journal Article] A Japanese family with autosomal dominant oculocutaneous albinism type4. (2017)
  • Author(s): Oki R, Yamada K, Nakano S, Kimoto K, Yamamoto K, Kondo H, Kubota T.
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 58 Issue: 2 Pages: 1008-1016
  • DOI: 10.1167/iovs.16-20612
  • Peer Reviewed / Open Access
• [Journal Article] Three cases of pigmented cosmetic dermatitis-like eruptions associated with primary Sjogren syndrome or anti-SSA antibody. (2016)
  • Author(s): Takeo N, Sakai T, Saito-Shono T, Ishikawa K, Hatano Y, Katagiri K, Takahashi Y, Kawano K, Kimoto K, Kubota T, Eshima N, Kojima H, Fujiwara S.
  • Journal Title: J Dermatol. Volume: 43 Issue: 8 Pages: 947-50
  • DOI: 10.1111/1346-8138.13300
  • Peer Reviewed / Open Access