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Study on molecular mechanism causing autoimmune retinopathy

Research Project

Project/Area Number 25462723
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionSapporo Medical University

Principal Investigator

Hiroshi Ohguro  札幌医科大学, 医学部, 教授 (30203748)

Co-Investigator(Kenkyū-buntansha) 阿部 晃  札幌医科大学, 医学部, 講師 (70136927)
平岡 美紀  札幌医科大学, 医学部, 講師 (80246983)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords網膜 / 自己免疫性網膜症 / リカバリン / 腫瘍随伴神経症 / 癌関連網膜症 / 自己免疫 / 自己免疫網膜症 / TRPM1 / molecul;ar mimicry / recoverin
Outline of Final Research Achievements

To elucidate the molecular pathology in autoimmune retinopathy (AIR), regulatory mechanism of expressions of autoantigen causing AIR as well as what kinds of role of such autoantigen aberrantly expressed in malignant tumor cells or none tumor cells were examined. Recoverin was identified to be expressed in 30-70% of cancer tissues. We observed co-precipitation of G-protein-coupled-kinases (GRKs) and caveolin-1 with Rec from cell lysates of 293 or SSTW cells. Immunocytechemistry revealed that immunoreactivities toward recoverin within the cancer cells were almost identical to those toward GRKs and caveolin-1. The present data strongly suggests that aberrantly expressed recoverin should be involved in the GRK-dependent cellular regulation in cancer cells.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (35 results)

All 2017 2016 2015 2014 2013

All Journal Article (19 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 19 results,  Open Access: 4 results,  Acknowledgement Compliant: 2 results) Presentation (12 results) Book (4 results)

  • [Journal Article] Prolonged Ocular Inflammation in Endotoxin-Induced Uveitis in Lysosomal Phospholipase A2-Deficient Mice.2017

    • Author(s)
      Sawada K, Hiraoka M, Abe A, Kelly R, Shayman JA, Ohguro H.
    • Journal Title

      Curr Eye Res.

      Volume: 42 Issue: 4 Pages: 611-616

    • DOI

      10.1080/02713683.2016.1214967

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Acute Bilateral Photoreceptor Degeneration in an Infant After Vaccination Against Measles and Rubella.2017

    • Author(s)
      Kuniyoshi K, Hatsukawai Y, Kimura S, Fujino T, Ohguro H, Nakai R, Sunami K, Mishima SI, Sato T, Kusaka S, Suzuki Y, Shimomura Y.
    • Journal Title

      JAMA Ophthalmol.

      Volume: 印刷中 Issue: 5 Pages: 478-482

    • DOI

      10.1001/jamaophthalmol.2017.0380

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Preferential hydrolysis of truncated oxidized glycerophospholipids by lysosomal phospholipase A2.2017

    • Author(s)
      Abe A, Hiraoka M, Ohguro H, Tesmer JJ, Shayman JA.
    • Journal Title

      J Lipid Res.

      Volume: 58 Issue: 2 Pages: 339-349

    • DOI

      10.1194/jlr.m070730

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Acute Retinal Necrosis Associated with Epstein-Barr Virus in a Patient Undergoing Immunosuppressive Therapy.2016

    • Author(s)
      Oe C, Hiraoka M, Tanaka S, Ohguro H.
    • Journal Title

      Case Rep Ophthalmol.

      Volume: 12 Issue: 1 Pages: 195-201

    • DOI

      10.1159/000445372

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fluctuation of lysosomal phospholipase A2 in experimental autoimmune uveitis in rats.2016

    • Author(s)
      Ohkawa E, Hiraoka M, Abe A, Murata M, Ohguro H.
    • Journal Title

      Exp Eye Res.

      Volume: 149 Pages: 66-74

    • DOI

      10.1016/j.exer.2016.06.017

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effect of Antiglaucoma Medicine on Intraocular  Pressure in DBA/2J Mice.2016

    • Author(s)
      Sawada K, Hiraoka M, Ohguro H.
    • Journal Title

      Ophthalmic Research

      Volume: 55 Issue: 4 Pages: 205-211

    • DOI

      10.1159/000444057

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The signal intensity ratio of the optic nerve to ipsilateral frontal white matter is of value in the diagnosis of acute optic neuritis.2016

    • Author(s)
      Onodera M, Yama N, Hashimoto M, Shonai T, Aratani K, Takashima H, Kamo K, Nagahama H, Ohguro H, Hatakenaka M.
    • Journal Title

      Eur Radiol.

      Volume: 26 Issue: 8 Pages: 2640-2645

    • DOI

      10.1007/s00330-015-4114-4

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Augmentation of Lysosomal Phospholipase A2 Activity in the Anterior Chamber in Glaucoma.2015

    • Author(s)
      Hiraoka M, Abe A, Inatomi S, Sawada K, Ohguro H.
    • Journal Title

      Current Eye Research

      Volume: 19 Issue: 5 Pages: 1-6

    • DOI

      10.3109/02713683.2015.1056800

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Increase of lysosomal phospholipase A2 in aqueous humor by uveitis.2014

    • Author(s)
      Hiraoka M, Abe A, Lennikov A, Kitaichi N, Ishida S, Ohguro H
    • Journal Title

      Exp Eye Res

      Volume: 118. Pages: 13-19

    • DOI

      10.1016/j.exer.2013.09.018

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of several anti-glaucoma medications on the circadian intraocular pressure fluctuations in patients with primary open-angle glaucoma.2014

    • Author(s)
      Tanaka S, Watanabe M, Inatomi S, Umeda K, Yoshida K, Ohguro I, Ohguro H
    • Journal Title

      Journal of Ocular Pharmacology and Therapeutics

      Volume: 30 Issue: 1 Pages: 12-20

    • DOI

      10.1089/jop.2013.0121

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] IkappaB kinase-β inhibitor IMD-0354 beneficially suppresses retinal vascular permeability in streptozotocin-induced diabetic mice.2014

    • Author(s)
      Lennikov A, Hiraoka M, Abe A, Ohno S, Fujikawa T, Itai A, Ohguro H
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 55 Issue: 10 Pages: 6365-6373

    • DOI

      10.1167/iovs.14-14671

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Association of cryptogenic onganizing pneumonia in bilateral anterior uveitis.2014

    • Author(s)
      Fujimoto K, Hiraoka M, Inatomi S, Ohguro H
    • Journal Title

      Case Rep Ophthalmol

      Volume: 5 Issue: 3 Pages: 365-372

    • DOI

      10.1159/000369125

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Recoverin-associated retinopathy secondary to Warthin tumor of parotid gland.2014

    • Author(s)
      Machida S, Ohguro H, Ishida K, Suzuki M, Kawagishi K.
    • Journal Title

      Doc Ophthalmol

      Volume: 129 Issue: 2 Pages: 123-128

    • DOI

      10.1007/s10633-014-9456-8

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] A case of paraneoplastic optic neuropathy and outer retinitis positive for autoantibodies against collapsin response mediator protein-5, recoverin, and α-enolase.2014

    • Author(s)
      Saito M, Saito W, Kanda A, Ohguro H, Ishida S.
    • Journal Title

      BMC Ophthalmol.

      Volume: 14 Issue: 1 Pages: 5-5

    • DOI

      10.1186/1471-2415-14-5

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Site-dependent differences in density of sympathetic nerve fibers in muscle-innervating nerves of the human head and neck.2014

    • Author(s)
      Hosaka F, Katori Y, Kawase T, Fujimiya M, Ohguro H.
    • Journal Title

      Anat Sci Int.

      Volume: 89 Pages: 101-111

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of black currant anthocyanins on intraocular pressure in healthy volunteers and patients with glaucoma.2013

    • Author(s)
      Ohguro H, Ohguro I, Yagi S
    • Journal Title

      Journal of Ocular Pharmacology and Therapeutics

      Volume: 29(1) Issue: 1 Pages: 61-67

    • DOI

      10.1089/jop.2012.0071

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Qualitative changes in fetal trabecular meshwork fibers at the human iridocorneal angle.2013

    • Author(s)
      Hosaka F, Rodríguez-Vázquez JF, Abe H, Murakami G, Fujimiya M, Ohguro H
    • Journal Title

      Anat Cell Biol

      Volume: 46(1) Issue: 1 Pages: 49-56

    • DOI

      10.5115/acb.2013.46.1.49

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Black currant anthocyanins normalized abnormal levels of serum concentrations of endothelin-1 in patients with glaucoma.2013

    • Author(s)
      Yoshida K, Ohguro I, Ohguro H
    • Journal Title

      Journal of Ocular Pharmacology and Therapeutics

      Volume: 29(5) Issue: 5 Pages: 480-487

    • DOI

      10.1089/jop.2012.0198

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role of N-glycosylation of human lysosomal phospholipase A2 for the formation of catalytically active enzyme.2013

    • Author(s)
      Hiraoka M, Okamoto K, Ohguro H, Abe A
    • Journal Title

      J Lipid Res

      Volume: 54 Issue: 11 Pages: 3098-3105

    • DOI

      10.1194/jlr.m041640

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Instruction in basic techniques for cataract surgery using simulated models and diagrams.2014

    • Author(s)
      Hosaka F, Takemori T, Ohguro H
    • Organizer
      World Ophthalmology Congress
    • Place of Presentation
      Tokyo Forum Tokyo, Japan
    • Year and Date
      2014-04-02 – 2014-04-04
    • Related Report
      2014 Research-status Report
  • [Presentation] The involvement of lysosomal phospholipase A2 in glaucoma.2014

    • Author(s)
      Hiraoka M, Abe A, Inatomi S, Sawada K, Ohguro H
    • Organizer
      World Ophthalmology Congress
    • Place of Presentation
      Tokyo Forum Tokyo, Japan
    • Year and Date
      2014-04-02 – 2014-04-04
    • Related Report
      2014 Research-status Report
  • [Presentation] Cancer-associated retinopathy in a child with Langerhans cell histiocytosis.2014

    • Author(s)
      Hatsukawa Y, Hayashi M, Yasui M, Ohguro H
    • Organizer
      World Ophthalmology Congress
    • Place of Presentation
      Tokyo Forum Tokyo, Japan
    • Year and Date
      2014-04-02 – 2014-04-04
    • Related Report
      2014 Research-status Report
  • [Presentation] Case report of cancer-associated retinopathy with rapid onset severe visual loss.2014

    • Author(s)
      Murakami T, Namba H, Tomita Y, Ohguro H, Yamashita H
    • Organizer
      World Ophthalmology Congress
    • Place of Presentation
      Tokyo Forum Tokyo, Japan
    • Year and Date
      2014-04-02 – 2014-04-04
    • Related Report
      2014 Research-status Report
  • [Presentation] Involvement of lysosomal phospholipase A2 in endotoxin-induced uveitis mice.2014

    • Author(s)
      Sawada K, Abe A, Hiraoka M, Lennikov A, Ohguro H
    • Organizer
      World Ophthalmology Congress
    • Place of Presentation
      Tokyo Forum Tokyo, Japan
    • Year and Date
      2014-04-02 – 2014-04-04
    • Related Report
      2014 Research-status Report
  • [Presentation] The role of lysosomal phospholipase A2 in the experimental autoimmune uveitis model of rats.2014

    • Author(s)
      Ohkawa E, Lennikov A, Hiraoka M, Abe A, Ohguro H
    • Organizer
      World Ophthalmology Congress
    • Place of Presentation
      Tokyo Forum Tokyo, Japan
    • Year and Date
      2014-04-02 – 2014-04-04
    • Related Report
      2014 Research-status Report
  • [Presentation] Protective effect of yellow filter on light-induced retinal damage in rats.2014

    • Author(s)
      Hikage F, Lennikov A, Hiraoka M, Abe A, Ohguro H
    • Organizer
      World Ophthalmology Congress
    • Place of Presentation
      Tokyo Forum Tokyo, Japan
    • Year and Date
      2014-04-02
    • Related Report
      2014 Research-status Report
  • [Presentation] Connective tissue growth factor as a pathogen of proliferation of the retina in spontaneously diabetic torii rat.2013

    • Author(s)
      Maeda K, Ohguro I, Hiraoka M, Abe A, Ohguro H
    • Organizer
      The 8th APVRS Congress & The 52nd Annual meeting of Japanese Retina and Vitreous Society
    • Place of Presentation
      Nagoy, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] The lysosomal phospholipase A2 activity in aqueous humor of patients with retinal diseases.2013

    • Author(s)
      Sugawara A, Hiraoka M, Abe A, Ishikawa F, Ohguro H
    • Organizer
      The 8th APVRS Congress & The 52nd Annual meeting of Japanese Retina and Vitreous Society
    • Place of Presentation
      Nagoy, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] Low levels of plasma endothelin-1(ET-1)in patients with retinitis pigmentosa.2013

    • Author(s)
      Ohguro H, Nakazawa M
    • Organizer
      The 8th APVRS Congress & The 52nd Annual meeting of Japanese Retina and Vitreous Society
    • Place of Presentation
      Nagoy, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] A rare case of familial exudative vitreoretinopathy (FEVR) with Kabuki Make-Up Sydrome.2013

    • Author(s)
      Yoshida K, Watanabe M, Hikage F, Sugawara A, Ishikawa F, Ohguro H
    • Organizer
      The 8th APVRS Congress & The 52nd Annual meeting of Japanese Retina and Vitreous Society
    • Place of Presentation
      Nagoy, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] Clinicopathological roles of aberrantly expressed recoverin in malignant tumor cells.2013

    • Author(s)
      Watanabe M, Matsuo S, Ohguro I, Ohguro H
    • Organizer
      The 8th APVRS Congress & The 52nd Annual meeting of Japanese Retina and Vitreous Society
    • Place of Presentation
      Nagoy, Japan
    • Related Report
      2013 Research-status Report
  • [Book] 第9章 視神経.「標準眼科学 第12版(木下 茂・中澤 満・天野史郎 編集)」2013

    • Author(s)
      大黒 浩
    • Total Pages
      403
    • Publisher
      医学書院
    • Related Report
      2013 Research-status Report
  • [Book] Glaucoma 私のArchives房水循環のなぞ.「Frontiers in Glaucoma 第45号」2013

    • Author(s)
      大黒 浩
    • Total Pages
      88
    • Publisher
      メディカルレビュー社
    • Related Report
      2013 Research-status Report
  • [Book] IV その他の疾患 ④神経眼科疾患6視神経管骨折. 「眼科疾患最新の治療2013-2015(大橋裕一・白神史雄 編集)」2013

    • Author(s)
      大黒 浩
    • Total Pages
      376
    • Publisher
      南江堂
    • Related Report
      2013 Research-status Report
  • [Book] 1.検査と診察 サイエンテイフィック・クエスチョン 網膜が剥離すると視物質はどうなるのでしょうか?「専門医のための眼科診療クオリファイ⑰裂孔原性網膜剥離-How to treat(瓶井資弘編集)」2013

    • Author(s)
      大黒 浩
    • Total Pages
      386
    • Publisher
      中山書店
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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