Study on molecular mechanism causing autoimmune retinopathy
Project/Area Number |
25462723
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Ophthalmology
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Research Institution | Sapporo Medical University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
阿部 晃 札幌医科大学, 医学部, 講師 (70136927)
平岡 美紀 札幌医科大学, 医学部, 講師 (80246983)
|
Project Period (FY) |
2013-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 網膜 / 自己免疫性網膜症 / リカバリン / 腫瘍随伴神経症 / 癌関連網膜症 / 自己免疫 / 自己免疫網膜症 / TRPM1 / molecul;ar mimicry / recoverin |
Outline of Final Research Achievements |
To elucidate the molecular pathology in autoimmune retinopathy (AIR), regulatory mechanism of expressions of autoantigen causing AIR as well as what kinds of role of such autoantigen aberrantly expressed in malignant tumor cells or none tumor cells were examined. Recoverin was identified to be expressed in 30-70% of cancer tissues. We observed co-precipitation of G-protein-coupled-kinases (GRKs) and caveolin-1 with Rec from cell lysates of 293 or SSTW cells. Immunocytechemistry revealed that immunoreactivities toward recoverin within the cancer cells were almost identical to those toward GRKs and caveolin-1. The present data strongly suggests that aberrantly expressed recoverin should be involved in the GRK-dependent cellular regulation in cancer cells.
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Report
(5 results)
Research Products
(35 results)
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[Journal Article] Acute Bilateral Photoreceptor Degeneration in an Infant After Vaccination Against Measles and Rubella.2017
Author(s)
Kuniyoshi K, Hatsukawai Y, Kimura S, Fujino T, Ohguro H, Nakai R, Sunami K, Mishima SI, Sato T, Kusaka S, Suzuki Y, Shimomura Y.
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Journal Title
JAMA Ophthalmol.
Volume: 印刷中
Issue: 5
Pages: 478-482
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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