Demonstration of the Molecular Mechanism of Meibomian Lipids on the Determination of Dynamic Characteristics of the Tear Film Lipid Layer
| Project/Area Number |
25462728
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
Yokoi Norihiko 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (60191491)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 涙液油層 / 涙液液層 / 涙液層破壊 / ドライアイ / 界面化学 / 国際情報交換 / トポグラフィー / マイボーム腺機能不全 / マイボーム腺脂質 / レオロジー |
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| Outline of Final Research Achievements |
In collaboration with Dr. Georgi Georgiev of Sofia University, Sofia, Bulgaria, we investigated the viscoelastic property of meibomian lipids. Our results showed that the elastic property of meibomian lipids is predominant in healthy meibum, while the viscous property of those lipids is predominant in diseased meibum. These novel findings suggest that we need to rethink the traditional idea that the tear film lipid layer has the function of preventing the evaporation of aqueous tears from the tear film. In addition, our findings revealed that the lower saccade of the eye facilitates tear film breakup and that there are five different types of tear film breakup pattern. Thus, we developed a topographical analysis system that can quantitatively assess the five different types of tear film breakup.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Dry eye disease and work productivity loss in visual display users: the Osaka study2013
Author(s)
Uchino M, Uchino Y, Dogru M, Kawashima M, Yokoi N, Komuro A, Sonomura Y, Kato H, Kinoshita S, Schaumberg DA, Tsubota K
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Journal Title
Am J Ophthalmol
Volume: 157
Issue: 2
Pages: 294-300
DOI
Related Report
Peer Reviewed
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[Presentation] Evaluation of the validity of the diagnostic criteria for dry eye in Japan using subjective symptoms: Osaka study
Author(s)
Yokoi N, Uchino M, Uchino Y, Dogru M, Kawashima M, Komuro A, Sonomura Y, Kato H, Tsubota K, Kinoshita S
Organizer
The Association for Research in Vision and Ophthalmology
Place of Presentation
Seattle, U.S.A.
Related Report
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