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Individualization of treatment therapy for diabetic macular edema by laser speckle flowgraphy

Research Project

Project/Area Number 25462737
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionTokyo Medical University

Principal Investigator

Shimura Masahiko  東京医科大学, 医学部, 教授 (20302135)

Co-Investigator(Kenkyū-buntansha) YASUDA Kanako  東京医科大学, 医学部, 講師 (70647461)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords糖尿病黄斑浮腫 / 血流 / サイトカイン / 治療プロトコール / 網膜硝子体疾患 / 前房水 / 網膜血流 / 糖尿病網膜症 / 糖尿病 / 黄斑浮腫 / 加齢変化 / 眼循環圧
Outline of Final Research Achievements

The main cause of diabetic macular edema is considered to be retinal vascular deficiencies, and there are various types of treatment therapies, and also the sensitivity to each therapy is cknown to be case-dependent. In this study, using laser speckle flowgraphy, we successfully evaluate the dynamic change of blood flow volume in the retinal vessels. However, unfortunately, dynamic change of retinal blood flow volume after each treatment did not correlate with visual or morphologicl prognosis. Thus the limitation of this study with evaluation of blood flow volume was clarified. While response to anti-VEGF therapy for diabetic macular edema varies individually, and baseline humor aqueous concentrations of inflammatory cytokines reflect the number of IVR injections in the loading phase required to resolve DME.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (16 results)

All 2016 2015 2014

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Acknowledgement Compliant: 2 results) Presentation (9 results) (of which Int'l Joint Research: 1 results,  Invited: 4 results)

  • [Journal Article] Reduction of the frequency of intravitreal bevacizumab by posterior subtenon injection of triamcinolone acetonide in patients with diffuse diabetic macular edema2016

    • Author(s)
      Shimura M, Yasuda K, Minezaki T, Noma H
    • Journal Title

      Jpn J Ophthalmol

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of soluble vascular endothelial growth factor receptors-1 and -2, their ligands, and other factors in branch retinal vein occlusion with macular edema2014

    • Author(s)
      Noma, H., Mimura, T., Yasuda, K. and Shimura, M.
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 55 Issue: 6 Pages: 3878

    • DOI

      10.1167/iovs.14-13961

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Pulse waveform analysis of normal population using laser speckle flowgraphy.2014

    • Author(s)
      Tsuda, S., Kunikata, H., Shimura, M., Kunikata, H., Aizawa, N., Omodaka, K., Shiga, Y., Yasuda, M., Yokoyama, Y. and Nakazawa, T.
    • Journal Title

      Curr Eye Res

      Volume: 39 Issue: 12 Pages: 1207-1215

    • DOI

      10.3109/02713683.2014.905608

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Vascular endothelial growth factor and its soluble receptors-1 and -2 in Iris neovascularization and neovascular glaucoma2014

    • Author(s)
      Noma, H., Mimura, T., Yasuda, K. and Shimura, M.
    • Journal Title

      Ophthalmologica

      Volume: 232 Issue: 2 Pages: 102

    • DOI

      10.1159/000360303

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role of inflammation in diabetic macular edema2014

    • Author(s)
      Noma, H., Mimura, T., Yasuda, K. and Shimura, M.
    • Journal Title

      Ophthalmologica

      Volume: 232 Issue: 3 Pages: 127

    • DOI

      10.1159/000364955

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Relationship of skin autofluorescence to severity of retiniopathy in type 2 diabetes2014

    • Author(s)
      Yasuda M, Shimura M, ....Yasuda K,......Nakazawa T.
    • Journal Title

      Current Eye Research

      Volume: in press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Relative flow volume, a novel blood flow index in the human retina derived from laser speckle flowgraphy2014

    • Author(s)
      Shiga T, Shimura M, ......., Nakazawa T
    • Journal Title

      Investigative Ophthalmology & Visual Sciences

      Volume: in press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Vitreous concentrations of cytokines indicates visual prognosis after vitrectomy in patients with rhegmatogenous retinal detachment2016

    • Author(s)
      Shimura M, Motohashi R, Yasuda K, Noma H
    • Organizer
      2016 Annual Metting of Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Seatle USA
    • Year and Date
      2016-05-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dynamic change of aqueous concentrations of cytokines and their receptors during the clinical course of ranibizumab treatment in diabetic macular edema.2015

    • Author(s)
      Masahiko Shimura
    • Organizer
      Associartion for Research in Vision and Ophthalmology
    • Place of Presentation
      Denver
    • Year and Date
      2015-05-02 – 2015-05-07
    • Related Report
      2014 Research-status Report
  • [Presentation] Urrent opinion on optimal anti-VEGF for wAMD treatment2014

    • Author(s)
      Masahiko Shimura
    • Organizer
      2014 Annual Meeting of Taiwan Ophthalmological Scoiety
    • Place of Presentation
      Taipei
    • Year and Date
      2014-12-13 – 2014-12-15
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Comaparative evaluation of dynamic change of aqueous concentration of VEGF receptorsa between ranibizumab and aflibercept in patients with wet AMD2014

    • Author(s)
      Masahiko Shimura
    • Organizer
      American Academy of Ophthalmology 2014
    • Place of Presentation
      Chicago
    • Year and Date
      2014-10-16 – 2014-10-22
    • Related Report
      2014 Research-status Report
  • [Presentation] Efficacy and Safety of Intravitreal Aflibercept for Diabetic Macular Edema:VIVIDDME2014

    • Author(s)
      Masahiko Shimura
    • Organizer
      Asia Pacific Macula Meeting 2014
    • Place of Presentation
      Singapore
    • Year and Date
      2014-10-10 – 2014-10-12
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Current Treatment Approaches and Unmet medical needs in PCV among Asians2014

    • Author(s)
      Masahiko Shimura
    • Organizer
      Asia Pacific Macula Meeting 2014
    • Place of Presentation
      Singapore
    • Year and Date
      2014-10-10 – 2014-10-12
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Changes of Arterial and Venous Blood Flow Velocities at Retinal Bifurcations2014

    • Author(s)
      Shimura M, ......, Yasuda K, Noma H.
    • Organizer
      Asscosiation for Research and Vision in Ophthalmology 2014
    • Place of Presentation
      Orland FL, USA.
    • Related Report
      2013 Research-status Report
  • [Presentation] Dynamic change of aqueous concentrations of VEGF and its soluble receptors during the treatment of aflibercept in patients with age-related macular degeneration2014

    • Author(s)
      Tanaka A, ...., Yasuda K, Noma H, Shimura M
    • Organizer
      Asscosiation for Research and Vision in Ophthalmology 2014
    • Place of Presentation
      Orland FL, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] 硝子体手術の功罪「黄斑浮腫」2014

    • Author(s)
      志村雅彦
    • Organizer
      第118回日本眼科学会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
    • Invited

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Published: 2014-07-25   Modified: 2019-07-29  

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