| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
In this study we examined about the specific carbohydrate chains associated with refractory intraocular inflammations. Glycoblottoing which was newly developed carbohydrate structural analysis was performed with the serum of 2 groups; 1) Behcet’s disease patients who were refractory to infliximab treatment and were positive of anti-infliximab antibody. 2) Behcet’s disease patients who were well controlled with infliximab treatment. Four carbohydrate chains; m/z1680, m/z2337, m/z2379, m/z3195 were detected with significant difference between 2 groups, and all of them were increased in refractory patients.
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