| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
We previously reported that the 10-amino-acid fragment derived from the large fragment of rat mitochondrial calpain-1 have an inhibitory effect on the mitochondrial calpain-1. In the present study, we clarified that this peptide can be delivered to the rabbit retina by a topical instillation. In addition, we successfully made iPS cells from human skin fibroblasts for our future research projects. We also studied to examine whether or not the peptide derived from rats can demonstrate protective effects on human-derived cells such as ARPE-19 cells.
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