Strategy of photoreceptor protective treatment for retinitis pigmentosa
Project/Area Number |
25462746
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Ophthalmology
|
Research Institution | Hirosaki University |
Principal Investigator |
Metoki Tomomi 弘前大学, 医学部附属病院, 講師 (00400169)
|
Co-Investigator(Renkei-kenkyūsha) |
Nakazawa Mitsuru 弘前大学, 大学院医学研究科, 教授 (80180272)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 眼科学 / 網膜色素変性 / カルパイン / 眼薬理学 / ミトコンドリアカルパイン / iPS細胞 / 視細胞保護 / ペプチド療法 / ウサギ |
Outline of Final Research Achievements |
We previously reported that the 10-amino-acid fragment derived from the large fragment of rat mitochondrial calpain-1 have an inhibitory effect on the mitochondrial calpain-1. In the present study, we clarified that this peptide can be delivered to the rabbit retina by a topical instillation. In addition, we successfully made iPS cells from human skin fibroblasts for our future research projects. We also studied to examine whether or not the peptide derived from rats can demonstrate protective effects on human-derived cells such as ARPE-19 cells.
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Report
(4 results)
Research Products
(4 results)