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Development of novel device for ocular surface treatment with tranparent amnion membrane

Research Project

Project/Area Number 25462748
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionTohoku University

Principal Investigator

Yokokura Shunji  東北大学, 大学病院, 講師 (30400378)

Co-Investigator(Kenkyū-buntansha) TANAKA YUJI  国立研究開発法人理化学研究所, 情報基盤センター, 常任研究員 (40625513)
WATANABE RYO  東北大学, 大学院医学系研究科, 非常勤講師 (70625293)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords透明化積層化羊膜 / 組織工学 / 眼科学
Outline of Final Research Achievements

We made alternative corneal stroma having strenght and tranparency the same as normal corneal stroma with transparent human amniotic membrane laminates. When these laminates were tranplanted to rabbit cornea, these membranes survived for a long time. These laminates were useful for filling scleral defect and covering glaucoma shunt device. We manipulated scleral contact lens with these laminates. When this contact lens was worn on chemical injured rabbit cornea, inflammation on the ocular surface was reduced significantly. This contact lens might be effective for severe ocular surface inflammation.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (3 results)

All 2016 2015

All Presentation (3 results)

  • [Presentation] Multiplex PCRを用いた角膜保存液及びドナー・レシピエント角膜における微生物解析2016

    • Author(s)
      横倉俊二 丸山和一 杉田直 針谷威寛 外丸靖浩 清水則夫 中澤徹
    • Organizer
      第40回日本角膜学会・第31回日本角膜移植学会
    • Place of Presentation
      長野県軽井沢町 軽井沢プリンスホテルウエスト
    • Year and Date
      2016-02-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] 角膜感染症におけるMultiplex PCRによる病原体の検索とその有用性について2016

    • Author(s)
      針谷威寛 丸山和一 杉田直 横倉俊二 外丸靖浩 清水則夫 中澤徹
    • Organizer
      第40回日本角膜学会・第31回日本角膜移植学会
    • Place of Presentation
      長野県軽井沢町 軽井沢プリンスホテルウエスト
    • Year and Date
      2016-02-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] 化学架橋積層化ヒト羊膜の光学的、力学的特性の解析2015

    • Author(s)
      針谷 威寛、田中 佑治、横倉 俊二、中澤 徹
    • Organizer
      第39回日本角膜学会総会・第31回日本角膜移植学会総会
    • Place of Presentation
      高知市
    • Year and Date
      2015-02-12
    • Related Report
      2014 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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