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Analysis of genotypes and clinical features of uveitis caused by herpes viruses

Research Project

Project/Area Number 25462752
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Takase Hiroshi  東京医科歯科大学, 大学院医歯学総合研究科, 講師 (20451940)

Co-Investigator(Kenkyū-buntansha) 望月 學  東京医科歯科大学, 医学部, 非常勤講師 (10010464)
清水 則夫  東京医科歯科大学, 学内共同利用施設等, 准教授 (30226245)
Research Collaborator KAMOI Koju  東京医科歯科大学, 眼科, 講師 (40451942)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsぶどう膜炎 / 急性網膜壊死 / 虹彩炎 / 水痘帯状疱疹ウイルス / ヘルペス性虹彩炎 / PCR / ヘルペスウイルス性前部ぶどう膜炎 / 網羅的PCRシステム / 遺伝子型
Outline of Final Research Achievements

Varicella-zoster virus (VZV) can cause anterior uveitis or acute retinal necrosis. Although those two disease categories have some common features such as granulomatous uveitis or cause increased intraocular pressure, they are distinctly different diseases because anterior uveitis caused by VZV does not develop acute retinal necrosis, and vice versa. We conducted genotyping analysis by identifying the single nucleotide polymorphism of the open reading frames of VZV from the intraocular fluid of those two different diseases. So far, VZV from the intraocular fluid of both two diseases are classified to be Clade 2. We are continuously analyzing the genotyping of VZV focusing on the gene mutation of glycoprotein E in addition to the open reading frames. Besides the genotyping of VZV, we are developing new comprehensive PCR system to detect VZV and other pathogens simultaneously. We also identified characteristic feature of acute retinal necrosis in fluorescein angiography.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (6 results)

All 2016 2015

All Presentation (6 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Presentation] 急性網膜壊死の診断基準および治療指針2016

    • Author(s)
      高瀬博
    • Organizer
      第70回日本臨床眼科学会
    • Place of Presentation
      京都国際会議場、京都府、京都市
    • Year and Date
      2016-11-03
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] DNA精製操作不要の眼感染症網羅的迅速検査「Direct strip PCR」の開発2016

    • Author(s)
      中野聡子, 外丸靖浩, 杉田直, 高瀬博, 中室隆子, 久保田敏昭, 清水則夫
    • Organizer
      第50回日本眼炎症学会
    • Place of Presentation
      東京国際フォーラム、東京都、千代田区
    • Year and Date
      2016-07-01
    • Related Report
      2016 Annual Research Report
  • [Presentation] Establishment of a new comprehensive polymerase chain reaction (PCR) strip kit for diagnosing infectious eye diseases2016

    • Author(s)
      Satoko Nakano,Sunao Sugita, Yasuhiro Tomaru, Takako Nakamuro, Toshiaki Kubota, Hiroshi Takase, Manabu Mochizuki, and Norio Shimizu
    • Organizer
      ARVO 2016 Annual Meeting
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2016-05-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 急性網膜壊死の網膜動脈炎検出における蛍光眼底造影検査の比較検討2016

    • Author(s)
      赤池さやか、高瀬博 、大野京子
    • Organizer
      第120回日本眼科学会総会
    • Place of Presentation
      仙台国際センター、宮城県、仙台市
    • Year and Date
      2016-04-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 眼局所検体を用いた眼感染症の新しいPCR網羅的検査の開発2015

    • Author(s)
      杉田直、賽野阿佑美、高橋政代、外丸靖浩、清水則夫、高瀬博、中野聡子
    • Organizer
      第69回日本臨床眼科学会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-22
    • Related Report
      2015 Research-status Report
  • [Presentation] 新規眼感染症網羅的PCR検査ストリップを用いた眼感染症診断2015

    • Author(s)
      中野聡子、外丸靖浩、中室隆子、横山勝彦、高瀬博、杉田直、清水則夫、久保田敏昭
    • Organizer
      第69回日本臨床眼科学会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-22
    • Related Report
      2015 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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