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Study for chromatin dynamics during optic nerve regeneration

Research Project

Project/Area Number 25462753
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionSuzuka University of Medical Science (2014-2015)
Kanazawa University (2013)

Principal Investigator

Koriyama Yoshiki  鈴鹿医療科学大学, 薬学部, 准教授 (70397199)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords神経再生 / エピジェネティクス / レチノイン酸受容体 / ヒストンアセチル化 / 視神経 / 網膜神経節細胞 / 神経回路 / 中枢神経 / 中枢神経再生 / クロマチンリモデリング / 緑内障 / 生存 / 神経節細胞
Outline of Final Research Achievements

Like other CNS neurons, mature retinal ganglion cells (RGCs) cannot regenerate their axons after nerve injury due to loss of regenerative capacity. One of the reasons why they lose their capacity seems to be a dramatic shift in gene expression of RGCs under epigenetic modulation. In here, we found that levels of histone H3 lysine 9 acetylation decreased after birth in RGCs. This decrease showed good correlation with restriction of retinoic acid receptor β (RARβ) expression in RGCs after birth. Furthermore, we demonstrated that a histone deacetylase inhibitor, trichostatin A, induced axonal regeneration of adult rat RGCs through RARβ induction.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (24 results)

All 2016 2015 2014 2013

All Journal Article (16 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 16 results,  Open Access: 8 results,  Acknowledgement Compliant: 4 results) Presentation (6 results) Book (2 results)

  • [Journal Article] 中枢神経再生過程におけるレチノイン酸受容体βの必要性2016

    • Author(s)
      郡山 恵樹
    • Journal Title

      ビタミン

      Volume: 90 Pages: 126-127

    • NAID

      110010043286

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell Fate of Müller Cells During Photoreceptor Regeneration in an N-Methyl-N-nitrosourea-Induced Retinal Degeneration Model of Zebrafish.2016

    • Author(s)
      Ogai K, Hisano S, Sugitani K, Koriyama Y, Kato S.
    • Journal Title

      Adv Exp Med Biol.

      Volume: 854 Pages: 685-692

    • DOI

      10.1007/978-3-319-17121-0_91

    • NAID

      120005682636

    • ISBN
      9783319171203, 9783319171210
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A possible role of neuroglobin in the retina after optic nerve injury: a comparative study of zebrafish and mouse retina.2016

    • Author(s)
      Sugitani, K., Koriyama, Y., Ogai, K., Wakasugi, K., and Kato, S.
    • Journal Title

      Adv. Exp. Med. Res.

      Volume: 854 Pages: 671-675

    • DOI

      10.1007/978-3-319-17121-0_89

    • NAID

      120005682638

    • ISBN
      9783319171203, 9783319171210
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Nitric Oxide Synthase Activation as a Trigger of N-methyl-N-nitrosourea-Induced Photoreceptor Cell Death.2016

    • Author(s)
      Hisano S, Koriyama Y, Ogai K, Sugitani K, Kato S.
    • Journal Title

      Adv Exp Med Biol.

      Volume: 854 Pages: 379-384

    • DOI

      10.1007/978-3-319-17121-0_50

    • ISBN
      9783319171203, 9783319171210
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Glyceraldehyde caused Alzheimer's disease-like alterations in diagnostic marker levels in SH-SY5Y human neuroblastoma cells.2016

    • Author(s)
      Koriyama Y, Ogai K, Sugitani K, Hisano S, Kato S.
    • Journal Title

      Adv Exp Med Biol.

      Volume: 854 Pages: 237-243

    • DOI

      10.1007/978-3-319-17121-0_32

    • ISBN
      9783319171203, 9783319171210
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 中枢神経再生過程におけるレチノイドシグナルの重要性2015

    • Author(s)
      郡山恵樹、杉谷加代、大貝和裕、加藤 聖
    • Journal Title

      ビタミン

      Volume: 89 Pages: 348-349

    • NAID

      110009969989

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of neuronal nitric oxide synthase in N-methyl-N-nitrosourea-induced retinal degeneration in mice2015

    • Author(s)
      Koriyama Y, Hisano S, Ogai K, Sugitani K, Furukawa A, Kato S.
    • Journal Title

      J Pharmacol Sci

      Volume: 127 Issue: 3 Pages: 394-396

    • DOI

      10.1016/j.jphs.2015.02.008

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Upregulation of leukemia inhibitory factor (LIF) during the early stage of optic nerve regeneration in zebrafish.2014

    • Author(s)
      Ogai K, Kuwana A, Hisano S, Nagashima M, Koriyama Y, Sugitani K, Mawatari K, Nakashima H, Kato S.
    • Journal Title

      PLoS One.

      Volume: 9 Issue: 8 Pages: 1-13

    • DOI

      10.1371/journal.pone.0106010

    • NAID

      120005478665

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Function of Sox2 in ependymal cells of lesioned spinal cords in adult zebrafish.2014

    • Author(s)
      Ogai K, Nakatani K, Hisano S, Sugitani K, Koriyama Y, Kato S.
    • Journal Title

      Neurosci Res.

      Volume: 88 Pages: 84-87

    • DOI

      10.1016/j.neures.2014.07.010

    • NAID

      120005478666

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Heat shock protein 70 induction by valproic acid delays photoreceptor cell death by N-methyl-N-nitrosourea in mice.2014

    • Author(s)
      Koriyama Y, Sugitani K, Ogai K, Kato S.
    • Journal Title

      J Neurochem.

      Volume: 130 Issue: 5 Pages: 707-719

    • DOI

      10.1111/jnc.12750

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Nipradilol Promotes Axon Regeneration Through S-Nitrosylation of PTEN in Retinal Ganglion Cells.2014

    • Author(s)
      Koriyama Y, Kamiya M, Arai K, Sugitani K, Ogai K, Kato S.
    • Journal Title

      Adv Exp Med Biol.

      Volume: 801 Pages: 751-757

    • DOI

      10.1007/978-1-4614-3209-8_94

    • ISBN
      9781461432081, 9781461432098
    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Reciprocal Changes in Factor XIII and Retinal Transglutaminase Expressions in the Fish Retina During Optic Nerve Regeneration.2014

    • Author(s)
      Sugitani K, Ogai K, Koriyama Y, Kato S
    • Journal Title

      Adv Exp Med Biol.

      Volume: 801 Pages: 759-764

    • DOI

      10.1007/978-1-4614-3209-8_95

    • NAID

      120005478698

    • ISBN
      9781461432081, 9781461432098
    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Regeneration-associated genes on optic nerve regeneration in fish2014

    • Author(s)
      Ogai K, Nishitani M, Kuwana A, Mawatari K, Koriyama Y, Sugitani K, Nakashima
    • Journal Title

      Adv Exp Med Biol.

      Volume: 801 Pages: 441-446

    • DOI

      10.1007/978-1-4614-3209-8_56

    • ISBN
      9781461432081, 9781461432098
    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Reinnervation of central visual areas and recovery of visual functions following optic nerve regeneration in adult mice2014

    • Author(s)
      Koriyama Y, Kurimoto T, de Lima S, Benowitz L.
    • Journal Title

      Brain Nerve.

      Volume: 66 Pages: 265-272

    • NAID

      40020010388

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A molecular mechanism of optic nerve regeneration in fish : the retinoid signaling pathway2013

    • Author(s)
      Kato S, Matsukawa T, Koriyama Y, Sugitani K, Ogai K
    • Journal Title

      Prog Retin Eye Res.

      Volume: 37 Pages: 13-30

    • DOI

      10.1016/j.preteyeres.2013.07.004

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Requirement of Retinoic Acid Receptorβfor Genipin Derivative-Induced Optic Nerve Regeneration in Adult Rat Retina2013

    • Author(s)
      Koriyama Y, Takagi Y, Chiba K, Yamazaki M, Sugitani K, Arai K, Suzuki H, Kato S
    • Journal Title

      PLoS One

      Volume: 8 Issue: 8 Pages: e71252-e71252

    • DOI

      10.1371/journal.pone.0071252

    • NAID

      120005327241

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 機能再建を目指した中枢神経再生戦略2015

    • Author(s)
      郡山 恵樹
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸(神戸学院大学)
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] バルプロ酸によるHSP70発現誘導はMNUによる細胞死を抑制する2015

    • Author(s)
      郡山 恵樹
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      名古屋(名古屋国際会議場)
    • Year and Date
      2015-03-18 – 2015-03-20
    • Related Report
      2014 Research-status Report
  • [Presentation] メチルニトロソ尿素による新たな視神経細胞死誘導メカニズム2014

    • Author(s)
      郡山 恵樹、大貝 和裕、杉谷 加代、加藤 聖
    • Organizer
      第34回 日本眼薬理学会
    • Place of Presentation
      岐阜(長良川国際会議場)
    • Year and Date
      2014-09-13 – 2014-09-14
    • Related Report
      2014 Research-status Report
  • [Presentation] HSP70 induction delays photoreceptor cell death by MNU in mice2014

    • Author(s)
      Y Koriyama, S Hisano, K Ogai ,K Sugitani, S Kato
    • Organizer
      XVIth International Symposium on Retinal Degeneration
    • Place of Presentation
      アメリカ(アシロマーカンファレンスセンター)
    • Year and Date
      2014-07-13 – 2014-07-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 成熟ほ乳類におけるRARbeta再発現機構による視神経再生2013

    • Author(s)
      郡山 恵樹
    • Organizer
      第24回日本レチノイド研究会
    • Place of Presentation
      東京(星薬科大学)
    • Related Report
      2013 Research-status Report
  • [Presentation] 損傷後視神経の視覚中枢回路再建と視機能回復2013

    • Author(s)
      郡山 恵樹
    • Organizer
      第56回日本神経化学会
    • Place of Presentation
      京都(国際会館)
    • Related Report
      2013 Research-status Report
  • [Book] Neural Regeneration2015

    • Author(s)
      Y Koriyama, L Benowitz
    • Publisher
      Academic Press
    • Related Report
      2014 Research-status Report
  • [Book] Regenerative Biology of the Eye2014

    • Author(s)
      S deLima, Y Koriyama, T Kurimoto, L Benowitz
    • Publisher
      Springer
    • Related Report
      2014 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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