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The development of the new controlled release agent using a self-assembling peptide

Research Project

Project/Area Number 25462754
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionOsaka University

Principal Investigator

Hirokazu Sakaguchi  大阪大学, 医学(系)研究科(研究院), 寄附講座准教授 (80379172)

Co-Investigator(Kenkyū-buntansha) NISHIDA KOHJI  大阪大学, 医学系研究科, 教授 (40244610)
HAYASHI RYUHEI  大阪大学, 医学系研究科, 寄附講座准教授 (70535278)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Keywords網膜疾患 / 硝子体投与 / DDS / 自己集合性ペプチド / 自己集合性ペプチドゲル / 硝子体内投与
Outline of Final Research Achievements

When treating a disease pharmacologically, it is most effective to deliver a drug directly to the affected area. In retinal disease, intravitreal administration has been widely used and, often needed frequent dosing because the duration of effect of drug is short. Therefore it’s imperative that controlled release agent remaining effective for a long time is developed. We confirmed that a self-assembling peptide had an ability to release a drug slowly and the released drug had effect. Additionally, we checked that the controlled release agent could be administered intravitreally.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (4 results)

All 2016 2015 2014

All Presentation (4 results)

  • [Presentation] 抗VEGF抗体徐放剤の開発:徐放性および効果について2016

    • Author(s)
      坂口裕和、上杉晃司、西田幸二
    • Organizer
      第120回日本眼科学会総会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2016-04-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] Self-assembling peptide gel as controlled release drug carriers: Influence on the effect of Bevacizumab by being entraped in the gel2015

    • Author(s)
      Hirokazu Sakaguchi, Koji Uesugi, Kohji Nishida
    • Organizer
      2015 ARVO
    • Place of Presentation
      Colorado Convention Center, USA
    • Year and Date
      2015-05-03 – 2015-05-07
    • Related Report
      2014 Research-status Report
  • [Presentation] Self-assembling peptide gel as controlled release drug carriers: Influence on the effect of Bevacizumab by being entraped in the gel2015

    • Author(s)
      Hirokazu Sakaguchi, Koji Uesugi, Kohji Nishida
    • Organizer
      ARVO 2015
    • Place of Presentation
      Colorado Convention Center (USA)
    • Year and Date
      2015-05-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] Self-assembling peptide as controlled release drug carriers: Bevacizumab entrapment efficiency and controlled release2014

    • Author(s)
      Hirokazu Sakaguchi, Koji Uesugi, Kohji Nishida
    • Organizer
      ARVO 2014
    • Place of Presentation
      Orange County Convention Center, Orlando, Fla.
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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