Elucidation of viral keratitis pathogenesis by comprehensive molecular analyses
Project/Area Number |
25462755
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Ophthalmology
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Research Institution | Tottori University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
池田 欣史 鳥取大学, 医学部, 助教 (10444639)
宮崎 大 鳥取大学, 医学部附属病院, 講師 (30346358)
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Research Collaborator |
HARUKI Tomoko
KANDORI Michiko
SASAKI Shin-ichi
OHTANI Fumie
UOTANI Ryu
SHIMIZU Daisuke
YAKURA Keiko
SHIMIZU Yumiko
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Project Period (FY) |
2013-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | 単純ヘルペスウイルス / サイトメガロウイルス / 角膜内皮 / マイクロアレイ / IDO / 制御性T細胞 / IRF7 / RAGE / インターフェロン / 獲得免疫 / 自然免疫 / 角膜内皮細胞 / RAGE / 免疫制御 / サイトカイン / IDO1 |
Outline of Final Research Achievements |
Molecules were comprehensively analyzed in corneal endothelial cells infected with herpes simplex virus (HSV) and cytomegalovirus in vitro by microarray technique, and these analyses indicated the importance of molecules related with interferon signaling, pattern recognition receptors, and antigen presentation. Especially, indoleamine 2,3-dioxygenase (IDO)induced HSV antigen-specific regulatory T cells, and resulted in immune tolerance. Also interferon regulatory factor 7(IRF7) induced both innate and acquired immunity, and receptors for advanced glycation endproducts (RAGE) were related with the induction of interferon-β after HSV infection.
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Report
(5 results)
Research Products
(30 results)
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[Journal Article] The effect of topical application of 0.15% ganciclovir gel on cytomegalovirus corneal endotheliitis.2016
Author(s)
Koizumi N, Miyazaki D, Inoue T, Ohtani F, Kandori-Inoue M, Inatomi T, Sotozono C, Nakagawa H, Horikiri T, Ueta M, Nakamura T, Inoue Y, Ohashi Y, Kinoshita S.
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Journal Title
Br J Ophthalmology
Volume: May 3
Issue: 2
Pages: 114-119
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Indoleamine 2,3-dioxygenase 1 in corneal endothelial cells limits herpes simplex virus type 1-induced acquired immune response2015
Author(s)
Haruki T, Miyazaki D, Inata K, Sasaki S, Yamamoto Y, Kandori M, Yakura K, Noguchi Y, Touge C, Ishikura R, Touge H, Yamagami S, Inoue Y
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Journal Title
Br J Ophthalmol.
Volume: 99
Issue: 10
Pages: 1435-1442
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Clinical features and management of cytomegalovirus corneal endotheliitis: analysis of 106 cases from the Japan corneal endotheliitis study.2015
Author(s)
Koizumi N, Inatomi T, Suzuki T, Shiraishi A, Ohashi Y, Kandori M, Miyazaki D, Inoue Y, Soma T, Nishida K, Takase H, Sugita S, Mochizuki M, Kinoshita S, & Japan Corneal Endotheliitis Study Group
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Journal Title
Br J Ophthalmol
Volume: 99
Pages: 54-58
Related Report
Peer Reviewed
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[Journal Article] Multicenter clinical study of the herpes simplex virus immunochromatographic assay kit for the diagnosis of herpetic epithelial keratitis.2013
Author(s)
Inoue Y, Shimomura Y, Fukuda M, Miyazaki D, Ohashi Y, Sasaki H, Tagawa,Y, Shiota H, Inada N, Okamoto S, Araki-Sasaki K, Kimura T, Hatano H, Nakagawa,H, Nakamura S, Hirahara A, Tanaka K, and Sakuma H
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Journal Title
Br J Ophthalmol
Volume: 97
Issue: 9
Pages: 1108-1112
DOI
Related Report
Peer Reviewed
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[Presentation] Anti-viral agents2015
Author(s)
Inoue Y
Organizer
The 7th International Conference on Ocular Infections
Place of Presentation
Fira de Barcelona (Barcelona, Spain)
Year and Date
2015-09-03
Related Report
Int'l Joint Research / Invited
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[Presentation] CMV corneal endotheliitis2015
Author(s)
Inoue Y
Organizer
The 30th Asia-Pacific Academy of Ophthalmology Congress
Place of Presentation
Guangzhou Baiyun International Convention Center (Guangzhou, China)
Year and Date
2015-04-01
Related Report
Int'l Joint Research / Invited
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