| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
When F344 embryonic rat thymus was transplanted beneath the renal capsule of BALB/c nude mice, the mice acquired the immunity of mouse origin. Autoimmune regulator (aire) gene was expressed in the rat thymic medullary epithelial cells, and enough regulatory T cells (Treg) presented in the periphery, however severe organ-localized autoimmune diseases developed. When Treg population of the normal mouse was injected before the symptoms of autoimmune diseases developed in TG nude mice, the onset of the diseases has been prevented.
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