| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
We elucidated the regulation mechanisms via the innate immune system in the ocular surface epithelial cells, in particular, we focused the regulation mechanisms through the TLR3-EP3 interaction. We clarified that TLR3 stimulation could induce various gene expression in ocular surface epithelial cells, and the genes expression could be reduced by EP3 stimulation. In addition, we found that the upregulation of genes which were found in EP3 KO mice were canceled in TLR3/ EP3 double KO mice, suggesting that EP3 could suppress the TLR3 inducible gene expression.
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