| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Outline of Final Research Achievements |
Although neurons are normally unable to regenerate their axons after injury to the central nervous system, proinflammatory agents, such as zymosan, have been shown to cause retinal ganglion cells to regenerate axons through the injured optic nerve. However, the role of molecules and cell populations in mediating this phenomenon remains unclear. We showed that neutrophils, the first responders of the innate immune system, release oncomodulin, which plays a central role in zymosan-induced optic nerve regeneration.
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