Development of a new therapy to stimulate optic nerve regeneration and reconstruction of the visual function
| Project/Area Number |
25462764
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Tokyo Metropolitan Institute of Medical Science |
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Principal Investigator |
KURIMOTO Takuji 公益財団法人東京都医学総合研究所, 運動・感覚システム研究分野, 研究員 (50388815)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 視神経再生 / 好中球 / Oncomodulin / 炎症 / 視神経炎症 |
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| Outline of Final Research Achievements |
Although neurons are normally unable to regenerate their axons after injury to the central nervous system, proinflammatory agents, such as zymosan, have been shown to cause retinal ganglion cells to regenerate axons through the injured optic nerve. However, the role of molecules and cell populations in mediating this phenomenon remains unclear. We showed that neutrophils, the first responders of the innate immune system, release oncomodulin, which plays a central role in zymosan-induced optic nerve regeneration.
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Report
(4 results)
Research Products
(6 results)
