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Production of the surgical device for human iPS cell–derived retinal pigment epithelium transplantation

Research Project

Project/Area Number 25462765
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionKawasaki Medical School

Principal Investigator

Kiryu Junichi  川崎医科大学, 医学部, 教授 (80281096)

Co-Investigator(Kenkyū-buntansha) 鎌尾 浩行  川崎医科大学, 医学部, 講師 (30388946)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords網膜色素上皮細胞 / iPS細胞 / ヒトiPS細胞 / 網膜色素上皮 / 移植器具 / 医療用器具
Outline of Final Research Achievements

We successfully conducted transplantation of a hiPSC-RPE cell sheet into a patient with AMD as the first-in-human trial using hiPSCs. AMD lesion, which is 3.0 mm in diameter, requires a 3.0 x 3.0 mm graft, however the surgical device in current use is possible to transplant less than 1.3 x 3.0 mm grafts. Therefore, we produced a surgical device which is possible to transplant a 3.0 x 3.0 mm graft via 1.5 mm scleral wound. The suction port of the device was designed on the lateral side in the insertion direction and the inside of device was processed to be able to store a 3.0 x 3.0 mm grafts. The device is possible to transplant grafts larger than scleral wound.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (15 results)

All 2015 2014 2013 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (12 results) (of which Invited: 1 results)

  • [Journal Article] Objective Evaluation of the Degree of Pigmentation in Human iPS Cell-derived RPE.2014

    • Author(s)
      Hiroyuki Kamao,Michiko Mandai, Shunji Wakamiya, Junko Ishida, Katsutoshi Goto, Takaaki Ono, Taiji Suda, Masayo Takahashi, and Junichi Kiryu
    • Journal Title

      Invest. Ophthalmol. Vis. Sci.

      Volume: 55 Issue: 12 Pages: 8309-8318

    • DOI

      10.1167/iovs.14-14694

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Characterization of Human Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Cell Sheets Aiming for Clinical Application2014

    • Author(s)
      Kamao H, Mandai M, Okamoto S, Sakai N, Suga A, Sugita S, Kiryu J, Takahashi M.
    • Journal Title

      Stem Cell Reports

      Volume: 2 Issue: 2 Pages: 205-218

    • DOI

      10.1016/j.stemcr.2013.12.007

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Generation of retinal pigment epithelium from induced pluripotent stem cells showed polarized secretion of VEGF and PEDF2013

    • Author(s)
      Hiroyuki Kamao, Junko Ishida, Taiji Suda, Junichi Kiryu
    • Journal Title

      Kawasaki Medical Journal

      Volume: 39 Pages: 155-162

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] ヨウ素酸ナトリウム硝子体注射による片眼網膜色素上皮障害モデル動物の作製2015

    • Author(s)
      鎌尾浩行、石田順子、桐生純一
    • Organizer
      第14回日本再生医療学会
    • Place of Presentation
      横浜、パシフィコ横浜
    • Year and Date
      2015-03-20
    • Related Report
      2014 Research-status Report
  • [Presentation] ヒトiPS細胞由来RPEの色の客観的評価方法による成熟度の数値化2014

    • Author(s)
      鎌尾浩行、万代道子、若宮俊二、石田順子、後藤克聡、小野貴暁、須田泰二、高橋政代、桐生純一
    • Organizer
      第68回日本臨床眼科学会
    • Place of Presentation
      神戸、神戸ポートピアホテル
    • Year and Date
      2014-11-14
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Evaluation of Degree of Pigmentation as an Indicator of Maturation in hiPSC-RPE (78/80)2014

    • Author(s)
      Hiroyuki Kamao, Michiko Mandai, Katsutoshi Goto, Junichi Kiryu, Masayo Takahashi
    • Organizer
      ARVO Annual meeting 2014
    • Place of Presentation
      USA, Orlando, Orange County Convention Center
    • Year and Date
      2014-05-05
    • Related Report
      2014 Research-status Report
  • [Presentation] ヒトiPS細胞由来網膜色素上皮細胞の色の客観的評価と機能との相関性2014

    • Author(s)
      鎌尾浩行、後藤克聡、高橋政代、桐生純一
    • Organizer
      第117回日本眼科学会
    • Place of Presentation
      東京、東京国際フォーラム
    • Year and Date
      2014-04-03 – 2014-04-06
    • Related Report
      2014 Research-status Report
  • [Presentation] Development of a Novel Device and Surgery for Human iPSC-RPE Cell-Sheet Transplantation2014

    • Author(s)
      Hiroyuki Kamao, Michiko Mandai, Osamu Mita, Yoshihisa Harada, Junichi Kiryu, Masayo Takahashi
    • Organizer
      World Ophthalmology Congress 2014
    • Place of Presentation
      Tokyo, Tokyo international forum, Orange County Convention Center
    • Year and Date
      2014-04-02 – 2014-04-06
    • Related Report
      2014 Research-status Report
  • [Presentation] ヒトiPS細胞由来網膜色素上皮細胞の色の客観的評価と機能との相関性2014

    • Author(s)
      鎌尾浩行、後藤克聡、高橋政代、桐生純一
    • Organizer
      第118回日本眼科学会
    • Place of Presentation
      東京、東京国際フォーラム
    • Related Report
      2013 Research-status Report
  • [Presentation] Development of a Novel Device and Surgery for Human iPSC-RPE Cell-Sheet Transplantation2014

    • Author(s)
      Hiroyuki Kamao, Michiko Mandai, Osamu Mita, Yoshihisa Harada, Junichi Kiryu, Masayo Takahashi
    • Organizer
      World Ophthalmology Congress 2014
    • Place of Presentation
      Tokyo, Tokyo International Forum
    • Related Report
      2013 Research-status Report
  • [Presentation] Evaluation of Degree of Pigmentation as an Indicator of Maturation status in Human iPSC-RPE

    • Author(s)
      Hiroyuki Kamao, Katsutoshi Goto, Michiko Mandai, Masayo Takahashi, Junichi Kiryu
    • Organizer
      ARVO Annual meeting 2014
    • Place of Presentation
      Orlando, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] ヒトiPS細胞由来網膜色素上皮細胞の色素量の客観的評価方法の作製

    • Author(s)
      鎌尾浩行、後藤克聡、高橋政代、桐生純一
    • Organizer
      第60回川崎医科大学眼科学術会
    • Place of Presentation
      岡山、ホテルグランヴィア岡山
    • Related Report
      2013 Research-status Report
  • [Presentation] 当科におけるヒトiPS細胞の培養と網膜色素上皮細胞への分化誘導

    • Author(s)
      石田順子、鎌尾浩行、桐生純一
    • Organizer
      第60回川崎医科大学眼科学術会
    • Place of Presentation
      岡山、ホテルグランヴィア岡山
    • Related Report
      2013 Research-status Report
  • [Presentation] ヒトiPS細胞由来RPEの色の客観的評価方法による成熟度の数値化

    • Author(s)
      鎌尾浩行、後藤克聡、高橋政代、桐生純一
    • Organizer
      第13回日本再生医療学会
    • Place of Presentation
      京都、京都国際会館
    • Related Report
      2013 Research-status Report
  • [Presentation] iPS細胞を用いた網膜再生医療

    • Author(s)
      鎌尾浩行、桐生純一
    • Organizer
      第4回川崎医科大学学術集会
    • Place of Presentation
      岡山、川崎医科大学
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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