| Project/Area Number |
25462768
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
田中 拡 東北大学, 大学病院, 助教 (50579448)
仁尾 正記 東北大学, 医学系研究科, 教授 (70228138)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 胆道閉鎖症 / 予後 / microRNA / 網羅的解析 / 層別化 / 肝生検 / 治療 |
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| Outline of Final Research Achievements |
In this study, we comprehensively analyzed microRNA expression status using liver biopsy in biliary atresia patients. Furthermore, we evaluated a relationship between microRNA expression status and clinical status.
On the basis of comprehensive microRNA expression study, proposed prognostic factors were picked up by gene ontology analysis. The quantitative analysis using real-time PCR were performed in these proposed factors.
In this study, microRNA might play a crucial role in development of biliary atresia. Therefore, biliary atresia patients might be stratified in accordance with microRNA expression status.
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