Basic research on the pathophysiological sequences of neural development on the affected spinal cord using the animal model of spina bifida aperta

• Project/Area Number: 25462774
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatric surgery
• Research Institution: Okayama University
• Principal Investigator: Mominoki Katsumi 岡山大学, 自然生命科学研究支援センター, 教授 (70304615)
• Co-Investigator(Kenkyū-buntansha): HIRAYAMA HARUKO 岡山大学, 自然生命科学研究支援センター, 助教 (40635257)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 二分脊椎症 / 疾患モデル動物 / 歩行障害 / 神経発生異常 / 運動神経 / 神経伝導路 / モデル動物 / 病態解析 / 脊髄奇形 / 発生異常 / 運動神経細胞 / 運動機能障害 / 知覚伝導路 / 神経細胞発生異常

Outline of Final Research Achievements

This research was carried out to determine whether the neural disruption in spina bifida model animals with the leg dysfunction was occurred or not. the research suggested that the affected spinal cord to create spina bifida in the model lead to the neural disruption, regardless of the normal appearance of the developed spinal cord on the surface.