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Patch tracheoplasty in body tissue engineering using collagenous connective tissue membranes(biosheets)

Research Project

Project/Area Number 25462780
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatric surgery
Research InstitutionSaitama Medical University

Principal Investigator

Satake Ryosuke  埼玉医科大学, 医学部, 講師 (70597525)

Co-Investigator(Kenkyū-buntansha) KOMURA Makoto  東京大学, 医学部付属病院, 特任研究員 (10422289)
HOSHI Kazuto  東京大学, 医学部, 准教授 (30344451)
TABATA Yasuhiko  京都大学, 再生医科学研究所, 教授 (50211371)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsbiosheet / biotube / 気管再生 / 軟骨再生 / 気道再建 / 気管軟骨 / 硝子軟骨 / バイオチューブ / 気道再生 / バイオエアーチューブ / PLLA多孔体 / 新規足場素材 / 軟骨細胞
Outline of Final Research Achievements

【Background】The aim was to evaluate the use of biosheets(collagenous connective tissue membranes are useful for engineering cardiovascular tissue) as a potential substitute material on vivo in a rabit model.【Methods】Rectangular-shaped Gore-Tex was(Gruop 1) ,dermis(Group 2) and biosheets(Group3) implanted into the defect created in the midventral portion of the cervical trachea. Biosheets were prepared by embedding silicone moulds in dorsal subcutaneous pouches in rabbits.【Main Results】All materials maintained airway structure for up to 4 weeks after implantation. Regenetive cartilage in implanted biosheets in group 3 was confirmed by histological analysis. Tracheal epithelial regeneration occurred in the internal lumen of group 3. There were significant differences in the amounts of collagen type Ⅱ and glycosaminoglycan between group 3 and group 1 or 2.【Conclusion】We confirm that cartilage can self-regenerate onto an airway patch using biosheets.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (18 results)

All 2016 2015 2014 2013 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (14 results) (of which Int'l Joint Research: 3 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Patch tracheoplasty in body tissue engineering using collagenous connective tissue membranes (biosheets)2015

    • Author(s)
      K. Hoshi et al
    • Journal Title

      J Pediatr Surg

      Volume: 51(2) Issue: 2 Pages: 244-8

    • DOI

      10.1016/j.jpedsurg.2015.10.068

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Promotion of tracheal cartilage growth by intra-tracheal injection of basic fibroblast growth factor (b-FGF).2014

    • Author(s)
      古村 眞
    • Journal Title

      J Pediatr Surg

      Volume: 2 Issue: 2 Pages: 296-300

    • DOI

      10.1016/j.jpedsurg.2013.11.040

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The junction between hyaline cartilage and engineered cartilage in rabbits2013

    • Author(s)
      Komura M, Komura H, Otani Y, Kanamori Y, Iwanaka T, Hoshi K, Tsuyoshi T, Tabata Y
    • Journal Title

      Laryngoscope

      Volume: 123 Issue: 6 Pages: 1547-51

    • DOI

      10.1002/lary.23269

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 解剖学的に模倣された人工気管BIO-AIR-TUBE再生の研究2016

    • Author(s)
      古村 眞、古村浩子、中山泰秀
    • Organizer
      第15回日本再生医療学会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2016-03-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] 組織工学による下気道再生2016

    • Author(s)
      古村 眞、古村浩子、田畑泰彦、中山泰秀、星 和人、高戸 毅
    • Organizer
      第15回日本再生医療学会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2016-03-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] 次世代治療技術としての自己結合組織管による気道再建の研究2015

    • Author(s)
      古村 眞
    • Organizer
      第67回日本気管食道科学会
    • Place of Presentation
      ザ・クレイトン福島(福島県福島市)
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] バイオチューブと再生軟骨輪による複合的自己代替組織気管(バイオエアーチューブ)の研究2015

    • Author(s)
      古村 眞, 佐竹 亮介, 合原 巧, 小高 哲郎, 寺脇 幹, 古村 浩子, 中山 泰秀
    • Organizer
      第53回日本人工臓器学会
    • Place of Presentation
      東京ドームホテル(東京都文京区)
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] バイオチューブと再生軟骨輪による複合的自己代替組織気管(バイオエアチューブ)の研究2015

    • Author(s)
      古村 眞
    • Organizer
      第26回日本小児呼吸器外科研究会
    • Place of Presentation
      倉敷芸文館(岡山県倉敷市)
    • Year and Date
      2015-10-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] Basic research toward a cylinder-type regenerative airway (BIO-AIR-TUBE)2015

    • Author(s)
      Ryosuke Satake, Makoto Komura, Hiroko Komura, Yasuhide Nakayama
    • Organizer
      2015 TERMIS WORLD CONGRESS
    • Place of Presentation
      Boston, USA
    • Year and Date
      2015-09-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PATCH TRACHEOPLASTY BY IN BODY TISSUE ENGINEERING USING COLLAGENOUS CONNECTIVE TISSUE MEMBRANES (BIOSHEETs)2015

    • Author(s)
      Ryosuke Satake, Makoto Komura, Hiroko Komura, Tetsuro Kodaka, Kan Terawaki,
    • Organizer
      Britisch Association of Pediatric Surgeons2015
    • Place of Presentation
      Cardiff, United Kingdom
    • Year and Date
      2015-07-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PATCH TRACHEOPLASTY BY IN BODY TISSUE ENGINEERING USING COLLAGENOUS CONNECTIVE TISSUE MEMBRANES (BIOSHEETS)2015

    • Author(s)
      Makoto Komura, Ryousuke Satake, Hiroko Komura, Yasuhide Nakayama
    • Organizer
      BAPS2015
    • Place of Presentation
      Cardiff, England
    • Year and Date
      2015-07-22
    • Related Report
      2014 Research-status Report
  • [Presentation] 円柱型再生気道の基礎的研究2015

    • Author(s)
      古村 眞, 佐竹 亮介, 鈴木 啓介, 小高 哲郎, 寺脇 幹,池袋 賢一, 米川 浩伸, 古村 浩子, 中山 泰秀
    • Organizer
      第52回日本小児外科学会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-05-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 円柱型再生気道の基礎的研究2015

    • Author(s)
      古村 眞 佐竹亮介 鈴木啓介 小高哲郎 寺脇 幹 中山泰秀
    • Organizer
      第52回日本小児外科学会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-05-28
    • Related Report
      2014 Research-status Report
  • [Presentation] Basic research toward a cylinder-type regenerative airway (BIO-AIR-TUBE)2015

    • Author(s)
      Makoto Komura, Ryousuke Satake, Hiroko Komura, Tetsuro Kodaka, Kan Terawaki,
    • Organizer
      Pacific Association of Pediatric Surgeons 2015
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      2015-05-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Basic research toward a cylinder-type regenerative airway (BIO-AIR-TUBE)2015

    • Author(s)
      Makoto Komura, Ryousuke Satake,  Hiroko Komura, Yasuhide Nakayama
    • Organizer
      PAPS2015
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      2015-05-17
    • Related Report
      2014 Research-status Report
  • [Presentation] Biosheetを用いた気道再建2014

    • Author(s)
      佐竹亮介, 古村 眞, 中山泰秀, 寺脇 幹, 小高哲郎, 鈴木啓介, 古村浩子
    • Organizer
      日本人工臓器学会
    • Place of Presentation
      京王プラザホテル札幌(北海道札幌市)
    • Year and Date
      2014-10-14
    • Related Report
      2014 Research-status Report
  • [Presentation] 生体内組織形成術を利用した自己組織代替組織気管(バイオエアチューブ) 開発コンセプトと試作

    • Author(s)
      古村 眞、佐竹 亮介, 寺脇 幹, 小高 哲郎, 小西 健一郎, 鈴木 啓介, 中山 泰秀, 岩井 良輔
    • Organizer
      第51回 日本人工臓器学会大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Patent(Industrial Property Rights)] 人工気管、人工気管の生産方法、及び人工気管形成用基材2014

    • Inventor(s)
      国立大学法人東京大学 独立行政法人国立循環器病研究センター
    • Industrial Property Rights Holder
      国立大学法人東京大学 独立行政法人国立循環器病研究センター
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-08-05
    • Related Report
      2014 Research-status Report
    • Overseas

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Published: 2014-07-25   Modified: 2019-07-29  

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