Basic research on Photodynamic Therapy in pediatric refractory cancer

• Project/Area Number: 25462784
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatric surgery
• Research Institution: National Center for Child Health and Development
• Principal Investigator: Watanabe Toshihiko 国立研究開発法人国立成育医療研究センター, 外科, 医師 (50306734)
• Co-Investigator(Renkei-kenkyūsha): Okita Hajime 慶應義塾大学, 病理学教室, 准教授 (50317260) ; Kuroda Tatsuo 慶應義塾大学, 小児外科学教室, 教授 (60170130) ; Rii Kou 国立成育医療研究センター, RI管理室, 室長 (60321890)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 難治性小児固形腫瘍 / 光線力学的治療 / 難治性固形腫瘍 / 神経芽腫

Outline of Final Research Achievements

5-aminolevurinic acid (5-ALA) induced apoptosis of tumor cells by promoting accumulation of intra-cellular PpIX in time and concentration dependent manner in pediatric neuroblastoma cell line. For future prospect, investigations on the effect of 5-ALA in vivo is needed.