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Development and technical refinement of supermicrosurgical composite tissue allograft and small organ transplant model

Research Project

Project/Area Number 25462786
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Plastic surgery
Research InstitutionThe University of Tokyo

Principal Investigator

Iida Takuya  東京大学, 医学部附属病院, 講師 (00398603)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords超微小血管吻合 / 同種複合組織移植 / 眼球移植 / マイクロサージャリー
Outline of Final Research Achievements

Several types of small organ transplantation model using supermicrosurgical technique have been developed and technically refined. In eye transplant model, vascularized peripheral nerve graft using median and facial nerve was inserted into sclera from a stub incision. Although a small number of nerve were regenerated, the rate was low. Side-to-end anastomosis in small arteries has also been developed to match size discrepancy between small vascular pedicle in organs and relatively large recipient vessels. Good patency rates were observed. In uterus transplantation model, improvements in microvascular anastomosis were developed including the location of anastomosis and selection of the pedicle.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (2 results)

All 2015 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (1 results)

  • [Journal Article] Uterus allotransplantation in cynomolgus macaque: A preliminary experience with non-human primate models.2014

    • Author(s)
      Suganuma N, Aoki D.
    • Journal Title

      J Obstet Gynaecol Res.

      Volume: 40(4) Issue: 4 Pages: 907-18

    • DOI

      10.1111/jog.12302

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Is “Eye” Transplantation Possible? Effect of Vascularized Nerve graft for Optic Nerve Regeneration; A Preliminary Report2015

    • Author(s)
      Takuya Iida
    • Organizer
      Byron bay meeting
    • Place of Presentation
      Gold Coast, Australia
    • Year and Date
      2015-03-02 – 2015-03-05
    • Related Report
      2014 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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