| Project/Area Number |
25462790
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Kobe University |
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Principal Investigator |
NOMURA TADASHI 神戸大学, 医学部附属病院, 講師 (30529566)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAKIBARA SHUNSUKE 神戸大学, 医学研究科, 特定助教 (50444592)
TERASHI HIROTO 神戸大学, 医学部附属病院, 教授 (80217421)
HASHIKAWA KAZUNOBU 神戸大学, 医学部附属病院, 准教授 (90403237)
江尻 浩隆 神戸大学, 医学部附属病院, 助教 (70529552)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 血管奇形 / 動静脈奇形 / 成長ホルモン受容体 / 増殖能 / 血管内皮細胞 / 成長ホルモン / vascular malformation / growth hormone receptor |
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| Outline of Final Research Achievements |
It was reported growth hormone receptor was overexpressed in the vessels of vascular malformations, especially in arteriovenous malformations. Tissue specimens(arteriovenous malformation(AVM), normal artery) were collected from patients undergoing resection or free flap transfer. AVM-derived vascular endothelial cell(AVMVEC) were prrimally cultured by explant method. Immunohistchemistry was used in paraffin‐embedded tissue and AVMVEC. Growth hormone receptor expression was observed in half the paraffin‐embedded AVM tissue, but in no AVMVEC. Proliferative ability of AVMVEC was as the same degree as human umbilical vein endothelial cells. In our study, growth hormone might not contribute to the expansion of arteriovenous malformation. However the proliferative ability of AVMVEC was very high, so some internal or external factor might effect the AVMVEC. Further investigation is needed.
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