Homosexual genital organ transplantation and analysis of germ cell trafficking

• Project/Area Number: 25462792
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Plastic surgery
• Research Institution: Okayama University
• Principal Investigator: NAMBA YUZABURO 岡山大学, 大学病院, 教授 (00335605)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 生殖臓器移植 / 性同一性障害 / 生殖細胞導入

Outline of Final Research Achievements

Reconstruction of the reproductive function with genital organ transplantation is important theme for patients who has gender identity disorder or reproductive disorder due to tumor resection.We modified our super-microsurgical testis transplantation procedure at homosexual model, and acquired minimally invasive result. In the testis transplantation models, we recognized testosterone secretion and sperm formation at higher rate.In the ovary transplantation models, we recognized estrogen secretion and pregnancy. In the transplantation model using GFP-transgenic rats, germ cell trafficking could not be demonstrated. We established penis transplant procedure. And we would like to improve this method to penis-testis co-transplantation.