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Effect of platelet rich plasma and bFGF in in-vivo tissue engineered vascularized soft tissue flap

Research Project

Project/Area Number 25462794
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Plastic surgery
Research InstitutionKagawa University

Principal Investigator

TANAKA Yoshio  香川大学, 医学部, 教授 (50171806)

Co-Investigator(Renkei-kenkyūsha) HAMAMOTO yhusuke  香川大学, 医学部形成外科, 助教 (10380180)
UENO Masaki  香川大学, 医学部炎症病理, 教授 (30322267)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords再生医療 / 血管付加組織 / in vivo chamber / 多血小板血漿 / bFGF / collagen sponge / 徐放性bFGF / chamber / 血管束 / 徐放性 / 再生組織 / 血管付加 / 徐放化 / チャンバー / in vivo / PRP / FGF-2
Outline of Final Research Achievements

(Purpose) Evaluate the effectiveness of platelet rich plasma (PRP) in tissue-engineered vascularized soft tissue flaps in in-vivo chamber. (Materials and methods) Animals: Japanese white male rabbit, Chamber was used as protected space for tissue engineering, pedicle vascular bundle for vascular source, collagen sponge for scaffold of cell migration. PRP and bFGF were additionally used as growth factors and the most effective combination to get a lager and more matulated granulation tissue was evaluated. Results) Additional use of PRP prevented the white, bean-curd-like debris, which was thought to be degradation of collagen sponge as a result of foreign body reaction in the previous experiments. The combination of activated PRP and controlled release bFGF showed the most effectiveness for generation of vascularized soft tissue flaps.These results suggested the usefulness of PRP in the clinical application of in vivo tissue-engineering vascularized soft tissue flap.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (7 results)

All 2015 2014 2013

All Presentation (7 results)

  • [Presentation] 乳房再建を目指したin vivo Tissue engineering Vascularized Fat Flapの作製2015

    • Author(s)
      田中 嘉雄
    • Organizer
      第45回日本創傷治癒学会
    • Place of Presentation
      東京
    • Year and Date
      2015-11-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] 臨床応用を目指したin vivo Tissue Engineering Vascularized Fat Flapの作製2015

    • Author(s)
      田中 嘉雄
    • Organizer
      第5回DDS再生医療研究会
    • Place of Presentation
      大阪
    • Year and Date
      2015-11-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] in vivo Tissue engineering chamberを用いた血管付加軟組織の再生2015

    • Author(s)
      田中 嘉雄
    • Organizer
      第24回日本形成外科学会基礎学術集会
    • Place of Presentation
      岩手県民会館
    • Year and Date
      2015-10-08 – 2015-10-09
    • Related Report
      2014 Research-status Report
  • [Presentation] in vivo Tissue engineering chamberを用いた血管付加脂肪組織の再生2014

    • Author(s)
      田中嘉雄
    • Organizer
      第13回再生医療学会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2013 Research-status Report
  • [Presentation] In vivo Tissue engineering chamberを用いた血管付加脂肪組織の作製2013

    • Author(s)
      田中嘉雄
    • Organizer
      第22回日本形成外科学会基礎学術集会
    • Place of Presentation
      朱鷺メッセ 新潟コンベンションセンター
    • Related Report
      2013 Research-status Report
  • [Presentation] In vivo Tissue engineering chamberを用いたvascularized skin flap作製の実験的研究2013

    • Author(s)
      田中嘉雄
    • Organizer
      第22回日本形成外科学会基礎学術集会
    • Place of Presentation
      朱鷺メッセ 新潟コンベンションセンター
    • Related Report
      2013 Research-status Report
  • [Presentation] Vascularized skin flap2013

    • Author(s)
      Yoshio Tanaka
    • Organizer
      2013 World Society for Reconstructive Microsurgery
    • Place of Presentation
      Fairmount Chicago
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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