The relationship of hypoplasty of lymphatic system and secondary lymphedema

• Project/Area Number: 25462797
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Plastic surgery
• Research Institution: Yokohama City University
• Principal Investigator: Yamamoto Yasushi 横浜市立大学, 附属市民総合医療センター, 非常勤診療医 (00336554)
• Co-Investigator(Kenkyū-buntansha): 安村 和則 横浜市立大学, 医学研究科, 共同研究員 (40351621) ; 佐武 利彦 横浜市立大学, 附属市民総合医療センター, 准教授 (60271318)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: リンパ浮腫

Outline of Final Research Achievements

If we have the screening methods for the predisposition of secondary lymphedema, oncology patients have more choices of the treatment. Our hypothesis is that lymphatic hypoplasty predisposes patients undergoing lymphadenotomy to secondary lymphedema. We examined the relationship of lymphatic hypoplasty and secondary lymphedema.
Individual difference of lymphatic flow pattern was observed in extremities of rats. Individual difference in human study was also detected in clearance test of indocyanine green injected in peripheral lymphatic capillaries. However the clarification of predisposition to lymphedema in delayed clearance group was not challenged in this study. SPECT/CT image analysis suggested that abnormalities of lymphatic flow pattern were closely related to the lymphatic hypoplasty and the onset of secondary lymphedema.

Research Products

• [Journal Article] "MIni-Flow-Through" Deep Inferior Epigastric Perforator Flap for Breast Reconstruction with Preservation of Both Internal Mammary and Deep Inferior Epigastiric Vessels (2015)
  • Author(s): Satake T, Sugawara J, Yasumura K, Mikami T, Kobayashi S, Maegawa J
  • Journal Title: Archives of Plastic Surgery Volume: 42 Issue: 06 Pages: 783-787
  • DOI: 10.5999/aps.2015.42.6.783
  • Peer Reviewed / Open Access
• [Journal Article] Tertiary breast reconstruction using a free contralateral latissimus dorsi myocutaneous flap and contralateral internal mammary recipient vessel anastomosis (2015)
  • Author(s): Toshihiko Satake, Mayu Muto, Yuji Yasuoka, Yoshihiko Tamanoi, Miki Hishikawa, Jun Sugawara, Kazunori Yasumura, Shinji Kobayashi, Maegawa J
  • Journal Title: JPRAS Open Volume: 7 Pages: 44-99
  • Peer Reviewed / Open Access
• [Journal Article] Unilateral breast reconstruction using bilateral inferior gluteal artery perforator flaps (2015)
  • Author(s): T Satake, M Muto, M Ogawa, et al.
  • Journal Title: Plastic and Reconstructive Surgery Global Open Volume: 3
  • Peer Reviewed / Open Access
• [Journal Article] Breast reconstruction using free posterior medial thigh perforator flaps: intraoperative anatomical study and clinical results (2014)
  • Author(s): T Satake, M Muto, S Ko, et al.
  • Journal Title: Plastic and Reconstructive Surgery Volume: 134 Pages: 880-891
  • Peer Reviewed