| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
We investigated which polyunsaturated fatty acids were cytoprotective or not against cell death induced by proinflammatory cytokines. We found that the existence of double bonds in fatty acids was much more important, irrespective of whether they were omega3- or omega6- derived. The cytoproteictve effects of polyunsaturated fatty acids were observed in macrophage-related culture cells such as raw.264 cells, as well as human lung epithelial like-A549 cells. Among the long chain polyunsaturated fatty acids investigated, oleic acid is the most promising in terms of its broad safety margin. These findings are to raise a doubt with respect to the major role of arachidonic acid cascade in lipid-mediated proinflammatory pathophysiology.
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