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Analysis of delayed encephalopathy after carbon monoxide poisoning using novel MRI techniques

Research Project

Project/Area Number 25462817
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Emergency medicine
Research InstitutionNiigata University

Principal Investigator

TERAJIMA KENSHI  新潟大学, 医歯学総合病院, 特任教授 (00377160)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords核磁気共鳴画像(MRI) / 一酸化炭素中毒 / 遅発性脳症 / プロトン磁気共鳴スペクトロスコピー / 拡散テンソル画像 / 高気圧酸素療法 / プロトンMRスペクトロスコピー / 拡散テンソルイメージング / MRI / MRI / 拡散強調画像 / プロトンMRスペクトロスコピー / 脳機能解析
Outline of Final Research Achievements

The purposes of this project are: 1) to develop a method of analyzing brain injury by using novel MR techniques; 2) to elucidate pathogenesis of delayed encephalopathy after carbon monoxide (CO) poisoning; and 3) to propose standardized therapeutic strategies for CO poisoning. This report overviews the results of this project as follows. Firstly, we developed new methods of analyzing brain injury using proton magnetic resonance spectroscopy and diffusion tensor imaging, and applied these methods to various neurological disease including amyotrophic lateral sclerosis, myotonic dystrophy, and acute brain stroke. Secondly, we analyzed relationship between clinical severity of patients with CO poisoning and the number of times of hyperbaric oxygen therapy that the patients had received.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (8 results)

All 2016 2015 2014 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (5 results)

  • [Journal Article] Laryngeal stridor in multiple system atrophy: Clinicopathological features and causal hypotheses.2016

    • Author(s)
      Tetsutaro Ozawa, Kanako Sekiya, Nobutaka Aizawa, Kenshi Terajima, and Masatoyo Nishizawa
    • Journal Title

      Journal of Neurological Science

      Volume: 361 Pages: 243-249

    • DOI

      10.1016/j.jns.2016.01.007

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Apparent diffusion coefficients distinguish amyotrophic lateral sclerosis from cervical spondylotic myelopathy.2015

    • Author(s)
      Koike Y, Kanazawa M, Terajima K, Watanabe K, Ohashi M, Endo N, Shimohata T, Nishizawa M.
    • Journal Title

      Clin Neurol Neurosurg.

      Volume: 132 Pages: 33-6

    • DOI

      10.1016/j.clineuro.2015.02.009

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Diffuse brain abnormalities in myotonic dystrophy type 1 detected by 3.0 T proton magnetic resonance spectroscopy2015

    • Author(s)
      Takado Y, Terajima K, Ohkubo M, Okamoto K, Shimohata T, Nishizawa M, Igarashi H, Nakada T
    • Journal Title

      Eur Neurol

      Volume: 73 Issue: 3-4 Pages: 247-256

    • DOI

      10.1159/000371575

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 3T-MRIを用いた頭蓋内血管異常の臨床的検討2015

    • Author(s)
      上村昌寛、寺島健史、鈴木雄治、二宮格、赤岩靖久、五十嵐博中、 中田力、西澤正豊
    • Organizer
      第56回日本神経学会学術大会
    • Place of Presentation
      新潟市朱鷺メッセ
    • Year and Date
      2015-05-20 – 2015-05-23
    • Related Report
      2014 Research-status Report
  • [Presentation] 3T-MRIを用いた頭蓋内血管異常の臨床的検討2015

    • Author(s)
      上村昌寛、寺島健史、鈴木雄治、二宮格、赤岩靖久、五十嵐博中、 中田力、西澤正豊
    • Organizer
      第40回日本脳卒中学会総会
    • Place of Presentation
      広島市リーガルロイヤルホテル広島
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Research-status Report
  • [Presentation] A Significant Increase Of Apparent Diffusion Coefficients In Corticospinal Tracts Differentiates Amyotrophic Lateral Sclerosis From Cervical Spondylotic Myelopaty2014

    • Author(s)
      Yuka Koike, Masato Kanazawa, Kenshi Terajima, Kei Watanabe, Masayuki Ohashi, Naoto Endo, Takayoshi Shimohata, and Masatoyo Nishizawa
    • Organizer
      American Academy of Neurology 66th Annual Meeting
    • Place of Presentation
      Pennsylvania Convention Center, Philadelphia, USA
    • Year and Date
      2014-04-30
    • Related Report
      2014 Research-status Report
  • [Presentation] 筋萎縮性側索硬化症の診断における3T頭部MRI拡散強調画像の有用性の検討

    • Author(s)
      小池佑佳,金澤雅人,寺島健史,下畑享良,西澤正豊
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2013 Research-status Report
  • [Presentation] A Significant Increase Of Apparent Diffusion Coefficients In Corticospinal Tracts Differentiates Amyotrophic Lateral Sclerosis From Cervical Spondylotic Myelopaty

    • Author(s)
      Yuka Koike, Masato Kanazawa, Kenshi Terajima, Kei Watanabe, Masayuki Ohashi, Naoto Endo, Takayoshi Shimohata, and Masatoyo Nishizawa
    • Organizer
      American Academy of Neurology 66th Annual Meeting
    • Place of Presentation
      Pennsylvania Convention Center
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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