Blocking the interaction of coagulation and inflammation, and significance of vasoactive substances in DIC
| Project/Area Number |
25462818
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | DIC / 播種性血管内凝固症候群 |
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| Outline of Final Research Achievements |
Disseminated intravascular coagulation (DIC) is a serious disease that, in the presence of underlying disease, causes persistent, generalized, marked coagulation activation. Early treatment based on an appropriate diagnosis is very important for improving patients’ prognosis.
The commonly used conventional animal models of DIC are induced with LPS or tissue factor (TF), and they have been considered to be essentially the same pathologically. However, our group recently showed that the pathology differs greatly depending on the DIC inducer used, at the view point of coagulofibrinolytic activation, inflammation and vasoactive substances.
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] Late onset thrombosis in two Japanese patients with compound heterozygote protein S deficiency.2015
Author(s)
Taniguchi F, Morishita E, Sekiya A, Yamaguchi D, Nomoto H, Kobayashi E, Takata M, Kosugi I, Takeuchi N, Asakura H, Ohtake S.
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Journal Title
Thromb Res
Volume: in press
Issue: 6
Pages: 1221-1223
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Post-marketing surveillance of thrombomodulin alfa, a novel treatment of disseminated intravascular coagulation - Safety and efficacy in 1,032 patients with hematologic malignancy2014
Author(s)
Asakura H, Takahashi H, Tsuji H, Matsushita T, Ninomiya H, Honda G, Mimuro J, Eguchi Y, Kitajima I, Sakata Y
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Journal Title
Thromb Res
Volume: 133
Issue: 3
Pages: 364-370
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Antithrombin deficiency in three Japanese families: one novel and two reported point mutations in the antithrombin gene.2013
Author(s)
Maruyama K, Morishita E, Karato M, Kadono T, Sekiya A, Goto Y, Sato T, Nomoto H, Omi W, Tsuzura S, Imai H, Asakura H, Ohtake S, Nakao S.
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Journal Title
Thromb Res
Volume: 132
Issue: 2
Pages: e118-e123
DOI
Related Report
Peer Reviewed
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[Presentation] 後天性出血性疾患の臨床2015
Author(s)
朝倉英策
Organizer
第37回日本血栓止血学会学術集会
Place of Presentation
甲府市総合市民会館（山梨県甲府市）
Year and Date
2015-05-23
Related Report
Invited
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[Presentation] DICの臨床
Author(s)
朝倉英策
Organizer
第14回日本検査血液学会学術集会
Place of Presentation
京王プラザホテル（東京）
Related Report
Invited
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