Evaluation of brain metabolite for oxidative stress using microdialysis
| Project/Area Number |
25462821
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAWAKITA KENYA 香川大学, 医学部附属病院, 講師 (10505803)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 脳マイクロダイアリシス / 脳lactate/pyruvate / 脳ブドウ糖 / 心停止後症候群 / 心拍再開後脳障害 / マイクロダイアリシス / フリーラジカル / 重症脳障害 |
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| Outline of Final Research Achievements |
Cerebral microdialysis (CMD) is an efficient sampling technique to detect neurochemical changes in brain interstitial tissue, and it has become the most accurate in vivo method to monitor brain metabolism. However, the association between CMD metabolites and blood lactate and glucose with respect to neurological outcomes in patients with non-traumatic OHCA remains unknown. The aim of this study was to examine the association between CMD metabolites and blood lactate and glucose in relation to neurological outcomes in these patients. In the preliminary microdialysis study, alterations of brain metabolites, such as lactate/pyruvate and glucose, during therapeutic hypothermia are associated with the neurological outcome in patients with out-of hospital cardiac arrest.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Effect of Admission Glasgow Coma Scale Motor Score on Neurological Outcome in Out-of-Hospital Cardiac Arrest Patients Receiving Therapeutic Hypothermia2015
Author(s)
Toru Hifumi, Yasuhiro Kuroda, Kenya Kawakita, Hirotaka Sawano, Yoshio Tahara, Mamoru Hase, Kenji Nishioka, Shinichi Shirai, Hiroshi Hazui, Hideki Arimoto, Kazunori Kashiwase, Shunji Kasaoka, Tomokazu Motomura, Yuji Yasuga, Naohiro Yonemoto, Hiroyuki Yokoyama, Ken Nagao, Hiroshi Nonogi, the J-PULSE-Hypo Investigators
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Journal Title
Circulation Journal
Volume: 79
Issue: 10
Pages: 2201-2208
DOI
NAID
ISSN
1346-9843, 1347-4820
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Dissociation of the relationship between plasma and intraceberal concentration of glucose and lactate: A comparison between postcardiac arrest syndrome and traumatic brain injury2015
Author(s)
Yasuhiro Kuroda, Kenya Kawakita, Satoshi Egawa, Toru Hifumi, Masanobu Hagiike, Yuko Abe, Natsuyo Shinohara, Kazutaka Kiridume, Koshiro Takano, Hideyuki Hamaya, Tomoya Okazaki, Arisa Manabe
Organizer
13th Annual meeting of the Neurocritical Care Society
Place of Presentation
Scottsdale
Year and Date
2015-10-08
Related Report
Int'l Joint Research
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