| Project/Area Number |
25462830
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Emergency medicine
|
|---|
| Research Institution | Juntendo University |
|---|
Principal Investigator |
SUMI YUKA 順天堂大学, 医学部, 准教授 (40403084)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MATSUDA Akihisa 日本医科大学, 医学部, 助手 (00366741)
INOUE Yoshiaki 筑波大学, 医学部, 教授 (60379196)
TANAKA Hiroshi 順天堂大学, 医学部, 教授 (90252676)
SUEYOSHI Koichiro 順天堂大学, 医学部, 助手 (90648297)
|
|---|
| Research Collaborator |
Junger Wolfgang Harvard Medical School, Department of Surgery, Beth lsrael Medical Deaconess Center, Professor
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | ＳＩＲＳ / ＡＴＰ / ａｄｅｎｏｓｉｎｅ / Ｓｅｐｓｉｓ / ATP / adenosine / BMI / SIRS / 炎症 / ミトコンドリア機能不全 |
|---|
| Outline of Final Research Achievements |
First, our data showed ATP/adenosine unbalance in various SIRS condition, such as sepsis, post-cardiac arrest syndrome, and Burn. ATP is pro-inflammatory factor and adenosine is anti-inflammatory factor, that the purinergic signaling may define the inflammatory response.
Second, we found that the ATP and ATP/adenosine before elective surgery may define the inflammatory response after surgery. This finding is intriguing that we can provide the custom made care for each patient depending on his ATP/adenosine profile before surgery.The mechanism of the difference in ATP/adenosine profile is unknown, and need to be clarified.
|
