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Basic experiments for developing temporary packing material using a polymer gel to control solid organ hemorrhage

Research Project

Project/Area Number 25462834
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Emergency medicine
Research InstitutionNippon Medical School

Principal Investigator

Matsumoto Hisashi  日本医科大学, 医学部, 教授 (60242559)

Co-Investigator(Kenkyū-buntansha) YAGI Takanori  日本医科大学, 医学部, 助教 (00445785)
MASHIKO Kazuki  日本医科大学, 医学部, 助教 (40614805)
YASUMATSU Hiroshi  日本医科大学, 医学部, 助教 (80614809)
Co-Investigator(Renkei-kenkyūsha) HARADA Akira  大阪大学, 大学院理学研究科, 特任教授 (80127282)
YAMAGUCHI Hiroyasu  大阪大学, 大学院理学研究科, 教授 (00314352)
HASHITSUME Akihito  大阪大学, 大学院理学研究科, 准教授 (70294147)
TAKASHIMA Yoshinori  大阪大学, 大学院理学研究科, 助教 (40379277)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords体幹部外傷 / ダメージコントロール / パッキング / 超分子ゲル / シクロデキストリン / 止血 / 高分子ゲル / 肝損傷 / アクリルアミド
Outline of Final Research Achievements

Removing of towel or gauze applied as a temporary hemostasis in damage control surgery causes for re-bleeding. This study aimed to develop a new material using a polymer gel that enables safe removal from the damaged organ after hemostatic packing.A polyacrylamide-based hydrogel containing β-cyclodextrin (CD) and adamantine (βCD-Ad gel) was applied to the crushed surface of the lacerated liver of a female pig to ascertain whether it could serve as packing material for hemorrhage control. The hardness, attachment and removability of the βCD-Ad gel were macroscopically evaluated. The hardness and fragmentation of the βCD-Ad gel is useful in packing to the injured organ surface. This experiment suggests that the polymer gel may be used as packing material instead of conventional gauze or towel and that it does not cause re-bleeding on removal. Trauma surgeons might be able to use a revolutionary hemostatic material for abdominal organ injury.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (1 results)

All 2016

All Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] Fundamental experiment of developing temporary packing material using polymer gel to control solid organ hemorrhage2016

    • Author(s)
      Hisashi Matsumoto
    • Organizer
      European Congress of Trauma and Emergency Surgery 2016
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2016-04-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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