Pathopysiology of microwave-induced traumatic brain injury
| Project/Area Number |
25462835
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Nippon Medical School |
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Principal Investigator |
FUSE AKIRA 日本医科大学, 医学部, 准教授 (80238641)
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| Co-Investigator(Kenkyū-buntansha) |
KATAYAMA Akira 日本医科大学, 医学部, 助教 (10333113)
MATSUDA Yoko 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (20363187)
YOKOTA Hiroyuki 日本医科大学, 大学院医学研究科, 教授 (60182698)
NAGANO Masatoshi 日本医科大学, 医学部, 講師 (60271350)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 脳損傷 / マイクロウェーブ / 爆傷 / 実験頭部外傷 / TUNEL / アポトーシス / TUNEL法 / 側脳室脈絡膜 |
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| Outline of Final Research Achievements |
The present study aimed to evaluate the change in the number of neural cells and presence of apoptotic cells in rats for one month after expo¬sure to excessive microwave radiation. The rats were exposed to 3.0 kW of microwaves for 0.1 sec and were sacrificed after exposure. The neural cells were counted in the motor cortex and hippocampus [cornu ammonis 1 (CA1) and CA2] and the percentage of positive cells stained with terminal deoxynucleo¬tidyl transferase mediated deoxyuridine triphosphate nick end labeling (TUNEL) were also measured. There were no significant differences from the controls in the percentage of TUNEL positive cells in the motor cortex and hippocampus. The effects of microwave exposure on the brain remain unclear; however, microwave induced neurotrauma shows the same pathological changes as blast traumatic brain injury.
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Report
(4 results)
Research Products
(2 results)
