| Project/Area Number |
25462836
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Nippon Medical School |
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Principal Investigator |
Arai Masatoku 日本医科大学, 医学部, 助教 (60267127)
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| Co-Investigator(Kenkyū-buntansha) |
TSUKAMOTO Takeshi 日本医科大学, 医学部, 助教 (20626270)
MASUNO Tomohiko 日本医科大学, 医学部, 講師 (00318528)
YOKOTA Hiroyuki 日本医科大学, 医学部, 教授 (60182698)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 虚血再灌流障害 / 腎障害 / 腫瘍壊死因子 / Egr-1 / 腎虚血再灌流障害 / サイトカイン / 急性腎障害 / 虚血再還流障害 |
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| Outline of Final Research Achievements |
We examined the role of early growth response factor-1 (Egr-1) in renal ischemia-reperfusion (I/R) injury in mice. Serum levels of BUN and creatinine, and histologic changes of kidneys were significantly increased at 12 ~48 hours after renal I/R. Renal tissue levels of TNF and MPO activity were significantly increased at 3 and 6 hours after renal I/R respectively. The expression of Egr-1 by Western blot analysis, significantly increased at 60~90 min after renal I/R and decreasing thereafter. These observations suggest that the increase of Egr-1 expression may be involved with renal I/R injury through the production of TNF and accumulation of neutrophils in mice.
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