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Elucidation of the role of Early growth response factor (Egr)-1 in renal ischemia reperfusion injury in mice

Research Project

Project/Area Number 25462836
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Emergency medicine
Research InstitutionNippon Medical School

Principal Investigator

Arai Masatoku  日本医科大学, 医学部, 助教 (60267127)

Co-Investigator(Kenkyū-buntansha) TSUKAMOTO Takeshi  日本医科大学, 医学部, 助教 (20626270)
MASUNO Tomohiko  日本医科大学, 医学部, 講師 (00318528)
YOKOTA Hiroyuki  日本医科大学, 医学部, 教授 (60182698)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords虚血再灌流障害 / 腎障害 / 腫瘍壊死因子 / Egr-1 / 腎虚血再灌流障害 / サイトカイン / 急性腎障害 / 虚血再還流障害
Outline of Final Research Achievements

We examined the role of early growth response factor-1 (Egr-1) in renal ischemia-reperfusion (I/R) injury in mice. Serum levels of BUN and creatinine, and histologic changes of kidneys were significantly increased at 12 ~48 hours after renal I/R. Renal tissue levels of TNF and MPO activity were significantly increased at 3 and 6 hours after renal I/R respectively. The expression of Egr-1 by Western blot analysis, significantly increased at 60~90 min after renal I/R and decreasing thereafter. These observations suggest that the increase of Egr-1 expression may be involved with renal I/R injury through the production of TNF and accumulation of neutrophils in mice.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (17 results)

All 2015 2014 2013

All Journal Article (6 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (11 results)

  • [Journal Article] A novel technique for managing open abdomen with the combined use of mesh-mediated traction and the bilateral anterior rectus abdominis sheath turnover flap method: how to do it.2015

    • Author(s)
      Arai M, Kushimoto S, Kim S, Masuno T, Hagiwara J, Ishii H, et al.
    • Journal Title

      Surgery Today

      Volume: [Epub ahead of print] Issue: 10 Pages: 1-5

    • DOI

      10.1007/s00595-015-1133-3

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 【救急医療:現状と課題】 日常医療を支える救急医療 救急救命士による処置範囲拡大の意義2015

    • Author(s)
      横田裕行
    • Journal Title

      Pharma Medica

      Volume: 33 Pages: 19-22

    • Related Report
      2014 Research-status Report
  • [Journal Article] 【わが国においてAcute Care Surgeryをいかに整備するか?】 当院高度救命救急センターにおけるAcute Care Surgeonの育成カリキュラム2014

    • Author(s)
      金 史英
    • Journal Title

      日本腹部救急医学会雑誌

      Volume: 34巻5号 Pages: 1340-2242

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 急性期脳卒中における病院前救急システムの現状2014

    • Author(s)
      横田裕行
    • Journal Title

      脳卒中

      Volume: 36 Pages: 201-205

    • NAID

      130004873617

    • Related Report
      2014 Research-status Report
  • [Journal Article] 神経外傷治療の可視化】 外傷学における頭部外傷の位置づけ2014

    • Author(s)
      横田裕行
    • Journal Title

      脳神経外科ジャーナル

      Volume: 23 Pages: 942-950

    • Related Report
      2014 Research-status Report
  • [Journal Article] 深在性腎損傷に対する経カテーテル動脈塞栓術の役割2013

    • Author(s)
      柳 雅人
    • Journal Title

      日本泌尿器科学会雑誌

      Volume: 104 Pages: 688-696

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 急性腎不全の診断と治療2015

    • Author(s)
      新井正徳
    • Organizer
      日本救急看護学会救急看護セミナー
    • Place of Presentation
      榊原記念病院
    • Year and Date
      2015-07-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] 病院前救急診療に伴う心的外傷ストレス軽減を目的とした事前教育の効果2015

    • Author(s)
      増野智彦
    • Organizer
      第20回日本集団災害医学会総会・学術集会
    • Place of Presentation
      たましんRISURUホール
    • Year and Date
      2015-02-26 – 2015-02-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 病院前救急診療を行う医師の心理状況とその特性2014

    • Author(s)
      増野智彦
    • Organizer
      第9回日本病院前救急診療学会総会・学術集会
    • Place of Presentation
      東京医科歯科大学
    • Year and Date
      2014-12-05
    • Related Report
      2014 Research-status Report
  • [Presentation] 当センターICU入院患者における入院後VTE(Venous Thromboembolism)発生の検討2014

    • Author(s)
      塚本剛志
    • Organizer
      第42回日本救急医学会総会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2014-10-28 – 2014-10-30
    • Related Report
      2014 Research-status Report
  • [Presentation] 脳死下臓器提供数増加のための方策 臓器提供施設からの課題と対策2014

    • Author(s)
      横田裕行
    • Organizer
      第50回日本移植学会総会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2014-09-10 – 2014-09-12
    • Related Report
      2014 Research-status Report
  • [Presentation] A novel technique for managing open abdomen by combined use of mesh traction and anterior rectus abdominis sheath turnover flap: a report of two cases.2014

    • Author(s)
      新井正徳
    • Organizer
      2nd Joint Scientific Congress of KSACS and JSACS
    • Place of Presentation
      Korea Soul
    • Year and Date
      2014-04-12
    • Related Report
      2014 Research-status Report
  • [Presentation] A case of black esophagus due to alcoholic ketoacidosis: a case report of acute esophageal necrosis2014

    • Author(s)
      賀 亮
    • Organizer
      43rd Congress of the Society of Critical Care Medicine(SCCM)
    • Place of Presentation
      サンフランシスコ(Moscone Center South)
    • Related Report
      2013 Research-status Report
  • [Presentation] 閉腹困難なopen abdomenにおいて非吸収性メッシュによる牽引および両側腹直筋鞘前葉反転法が有効であった2例2013

    • Author(s)
      新井正徳
    • Organizer
      第41回日本救急医学会総会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2013 Research-status Report
  • [Presentation] JTASからみた病院選定困難事例(いわゆる東京ルール)の問題点2013

    • Author(s)
      荒木 尚
    • Organizer
      第41回日本救急医学会総会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2013 Research-status Report
  • [Presentation] 新しい専門医制度に対応する救急医学の教育プログラム 救急科専門医の質向上にむけた複数基本領域専門医取得の必要性2013

    • Author(s)
      増野智彦
    • Organizer
      第41回日本救急医学会総会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2013 Research-status Report
  • [Presentation] FACT時代を迎える外傷初期診療 外傷診療におけるCTの位置づけ CTを撮影しない勇気を2013

    • Author(s)
      金 史英
    • Organizer
      第41回日本救急医学会総会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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