The relationship between IL-18 polymorphism and gender difference in emergency intensive care unit

• Project/Area Number: 25462841
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Hyogo College of Medicine
• Principal Investigator: Kotani Joji 兵庫医科大学, 医学部, 教授 (80360270)
• Co-Investigator(Renkei-kenkyūsha): KUBOYAMA Kazutoshi 兵庫医科大学, 医学部, 講師 (00299116) ; UEDA Takahiro 兵庫医科大学, 医学部, 助教 (80412055) ; USAMI Makoto 神戸大学, 大学院保健学研究科, 教授 (00193855) ; ISHIKAWA Michiko 神戸大学, 大学院保健学研究科, 研究員 (40566121) ; YAMADA Isamu 兵庫医科大学, 医学部, 講師 (20593990) ; MIYAWAKI Atsushi 兵庫医科大学, 医学部, 助教 (90418963) ; NAKAO Atsunori 兵庫医科大学, 医学部, 教授 (40648169) ; TERASHIMA Mariko 兵庫医科大学, 医学部, 助教 (00412015) ; HASHIMOTO Atsunori 兵庫医科大学, 医学部, 助教 (50461083)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: IL-18 / 遺伝子多型 / 敗血症 / 性差 / 好中球 / 一塩基多型

Outline of Final Research Achievements

This study examined the relationship between the plasma IL-18 levels, IL-18 promoter polymorphism, and outcomes or pathological conditions of the patients in the emergency intensive care unit (ICU). Only sex, APACHE II score, and plasma IL-18 level were identified as independent predictors of mortality by multivariate analysis. The plasma IL-18 levels were correlated with APACHE II score, and the patients who did not survive showed significantly higher levels of plasma IL-18 as compared with survivors. Patients who did not survive and had the -607 CA genotype (CA/GC or CA/GG) showed significantly higher plasma IL-18 levels than survivors with the same genotype. However, there were no relationship between IL-18 promoter genotypes and pathological conditions (non-sepsis, sepsis, septic shock). And there were also no relationship between IL-18 promoter genotypes and the neutrophil ability or gender difference. Plasma IL-18 levels may be predictive of outcome in patients with sepsis.

Research Products

• [Journal Article] IL18 production and IL18 promoter polymorphisms correlate with mortality in ICU patients. (2014)
  • Author(s): Yamada T, Aoyama-Ishikawa M, Yamashita H, Fujiwara M, Usami M, Ueda T, Terashima M, Kohama K, Nakao A, Kotani J.
  • Journal Title: In Vivo Volume: 28 Pages: 391-396
  • Peer Reviewed
• [Journal Article] A simple scoring system based on neutrophil count in sepsis patients. (2014)
  • Author(s): Ueda T, Aoyama-Ishikawa M, Nakao A, Yamada T, Usami M, Kotani J.
  • Journal Title: Med Hypotheses Volume: 82 Pages: 382-386
  • DOI: 10.1016/j.mehy.2014.01.007
  • Peer Reviewed
• [Presentation] IL18 Production and IL18 Promoter Polymorphisms Correlate with Mortality in ICU Patients (2015)
  • Author(s): Taihei Yamada, Atsunori Nakao, Takaaki Osako, Hiroyuki Sakata, Michiko Ishikawa Aoyama, Hayato Yamashita, Makoto Usami, Takahiro Ueda, Keisuke Kohama, Joji Kotani
  • Organizer: 8th Asian Conference for Emergency Medicine
  • Place of Presentation: Taipei International Convention Center (Taipei, China)
  • Year and Date: 2015-11-07
  • Int'l Joint Research
• [Presentation] 血中IL18濃度とIL18プロモーター領域遺伝子多型はICU患者における死亡率と相関する (2014)
  • Author(s): 山田太平、小濱圭祐、寺嶋真理子、上田敬博、中尾篤典、小谷穣治
  • Organizer: 第42回日本救急医学会総会・学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2014-10-28 – 2014-10-30