Pathology Elucidation and a Novel Therapeutic Strategy Against Sepsis-associated Encephalopathy
Project/Area Number |
25462842
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Emergency medicine
|
Research Institution | Kurume University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
TAKASU Osamu 久留米大学, 医学部・救急医学講座, 教授 (90236216)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 敗血症 / 脳症 / エストロゲン / キヌレニン経路 / 盲腸結紮穿孔モデル / 重症敗血症 / 敗血症関連脳症 / CLPモデル / キヌレニン / 17βエストラジオール / L-キヌレニン / サイトカイン / 性ステロイドホルモン |
Outline of Final Research Achievements |
In recent years, tens of millions of people worldwide develop severe sepsis every year, with comorbid encephalopathy increasing mortality in particular. We developed a mouse sepsis model in an attempt to elucidate the mechanisms of sepsis-associated encephalopathy. The model we used was the cecal ligation and puncture (CLP) model. After confirming improvements of survival rate via estrogen and L-kynurenine administrations, detection of mRNA expressions of a kynurenine receptor, the aryl carbohydrate receptor, and a tryptophanase, the tryptophan 2,3-dioxygenase, in peritoneal exudate cells were determined, indicating the involvement of the kynurenine pathway. In this process, we successfully generated a modified model in which intraperitoneal abscess formation, which is considered to be a defect of the original model, can be highly-controlled.
|
Report
(4 results)
Research Products
(3 results)
-
-
[Presentation] Phase angle in bioimpedance analysis and fluid status in critically ill patients2015
Author(s)
Takasu O, Tashiro K, Niiyama S, Kambe T, Kannae T, Moroki M, Morita T, Nabeta M, Nakamura A, Shimojyo Y, Mori S, Sakamoto T
Organizer
World Congress of the Intensive and Critical Care Medicine
Place of Presentation
Seoul, Korea
Year and Date
2015-08-29
Related Report
Int'l Joint Research
-