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A novel therapeutic approach to severe burns by microskin grafts combined with ultra-thin nanosheets

Research Project

Project/Area Number 25462844
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Emergency medicine
Research InstitutionNational Defense Medical College

Principal Investigator

SAITOH Diazoh  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 防衛医学研究センター, 教授 (90531632)

Co-Investigator(Kenkyū-buntansha) 武岡 真司  早稲田大学, 理工学術院, 教授 (20222094)
小野 聡  東京医科大学, 医学部, 教授 (30531355)
宮崎 裕美  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 防衛医学研究センター, 助教 (30531636)
木下 学  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 医学教育部医学科専門課程, 准教授 (70531391)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords熱傷 / マイクロスキン / ナノシート / 感染制御 / 創傷被覆材 / 血管新生 / 創傷治癒 / 機能性ナノシート / 抗菌性 / 抗菌能 / 同種皮膚 / 上皮化
Outline of Final Research Achievements

Microskin grafting can be expanded more than 10-fold by mincing the skin grafts, and is an effective
method for the treatment of extensive burn injury. We recently fabricated biodegradable ultra-thin nanosheets, which have advantageous properties for their application as a wound dressing, such as transparency, tight adherence, and moisture permeability. This study aimed to investigate the efficacy of a microskin grafts (MSG) combined with nanosheets (NS) in the wound healing using burn wound models in mice. Treatment of the burn wounds with MSG/NS significantly accelerated the wound healing compared with non-treatment, characterized by an increased rate of re-epithelialization and remodeling. In addition, MSG/NS also enhanced platelet-derived growth factor expression and vascular networks of the wound bed in the early stages of repair. In conclusion, microskin grafting and nanosheets might be a possible new and effective procedure for repairing extensive burn wounds.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (13 results)

All 2016 2015 2014 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 1 results) Presentation (10 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Polylactic acid nanosheets in prevention of postoperative intestinal adhesion and their effects on bacterial propagation in an experimental model.2016

    • Author(s)
      Hinoki A, Saito A, Kinoshita M, Yamamoto J, Saitoh D, Takeoka S.
    • Journal Title

      Br J Surg.

      Volume: 103 Issue: 6 Pages: 692-700

    • DOI

      10.1002/bjs.10122

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sustainable antimicrobial effect of silver sulfadiazine-loaded nanosheets on infection in a mouse model of partial-thickness burn injury.2015

    • Author(s)
      Ito K, Saito A, Fujie T, Nishiwaki K, Miyazaki H, Kinoshita M, Saitoh D, Ohtsubo S, Takeoka S.
    • Journal Title

      Acta Biomater.

      Volume: 24 Pages: 87-95

    • DOI

      10.1016/j.actbio.2015.05.035

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of a ubiquitously transferrable silver-nanoparticle-loaded polymer nanosheet as an antimicrobial coating2015

    • Author(s)
      Keisuke Ito, Akihiro Saito, Toshinori Fujie, Hiromi Miyazaki, Manabu Kinoshita,Daizoh Saitoh, Shinya Ohtsubo, Shinji Takeoka
    • Journal Title

      Journal of Biomedical Materials Research Part B Applied Biomaterials

      Volume: 103 Issue: 3 Pages: 585-593

    • DOI

      10.1002/jbm.b.33429

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Activation of PPAR gamma protects against postburn infection by regulating innate immune response2016

    • Author(s)
      Miyazaki H, Kinoshita M, Nakashima H, Nakashima M, Tomura S, Seno S, Seki S, Saitoh D.
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県・宜野湾市)
    • Year and Date
      2016-12-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] PPAR-γ agonist protects burn-injured mice from bacterial infection2016

    • Author(s)
      Miyazaki H, Kinoshita M, Seno S, Tomura S, Seki S, Saitoh D.
    • Organizer
      The 18th Congress of International Society for Burn Injuries
    • Place of Presentation
      Miami (USA)
    • Year and Date
      2016-08-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] シンポジウム:培養皮膚とアログラフトを用いた重症熱傷ハイブリッド治療「マイクロスキン技術を応用した熱傷治療の有用性」2016

    • Author(s)
      宮崎 裕美, 木下 学, 川内 聡子, 佐藤 俊一, 齋藤 大蔵
    • Organizer
      第42回日本熱傷学会総会・学術集会
    • Place of Presentation
      シェラトン・グランデ・トーキョーベイホテル(千葉県・浦安市)
    • Year and Date
      2016-06-02
    • Related Report
      2016 Annual Research Report
  • [Presentation] bFGF担持ナノシートの開発と創傷治癒への応用2015

    • Author(s)
      青木伸峰, 清澤智晴, 木下学, 齋藤大蔵, 藤井麻央, 藤枝俊宣, 西脇圭亮, 武岡真司
    • Organizer
      第24回日本形成外科学会基礎学術集会
    • Place of Presentation
      盛岡
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report
  • [Presentation] 抗菌性を有した機能性ナノシートによる熱傷治療2015

    • Author(s)
      宮崎裕美, 木下学, 藤枝俊宣, 武岡真司, 齋藤大蔵
    • Organizer
      第41回日本熱傷学会総会・学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-06-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 小児腹膜炎における汚染手術での術後癒着軽減への挑戦~ PLAナノシートの癒着防止効果の特徴~2015

    • Author(s)
      檜 顕成, 齋藤 晃広, 木下 学, 谷水 長丸, 宮崎 裕美, 北川 大輝, 小岩井 和樹, 青笹 季文,山崎 民大, 守屋 智之, 野呂 拓史, 小野 聡, 齋藤 大蔵, 武岡 真司, 長谷 和生, 山本 順司
    • Organizer
      第115回日本外科学会定期学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-04-16
    • Related Report
      2015 Research-status Report
  • [Presentation] 銀含有機能性ナノシートの熱傷創に対する有用性評価2015

    • Author(s)
      宮崎裕美、伊藤佳祐、木下学、藤枝俊宣、武岡真司、齋藤大蔵
    • Organizer
      第23回日本熱傷学会 関東地方会
    • Place of Presentation
      日本医科大学(東京)
    • Year and Date
      2015-01-31
    • Related Report
      2014 Research-status Report
  • [Presentation] Application of a biodegradable nanosheet as a new dressing for burn wounds2014

    • Author(s)
      Miyazaki H, Kinoshita M, Ono S, Fujie T, Takeoka S, Saitoh D.
    • Organizer
      17th Congress of International Society for Burns Injuries
    • Place of Presentation
      Sydney (Australia)
    • Year and Date
      2014-10-14 – 2014-10-16
    • Related Report
      2014 Research-status Report
  • [Presentation] パネルディスカッション 熱傷基礎研究の最前線 超薄膜ナノシートを応用した熱傷治療2014

    • Author(s)
      宮崎裕美、木下学、小野聡、武岡真司、齋藤大蔵
    • Organizer
      第40回日本熱傷学会総会・学術集会
    • Place of Presentation
      ラフレ埼玉(埼玉)
    • Year and Date
      2014-06-05 – 2014-06-06
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 同種皮膚を用いた新規熱傷治療法 ―マイクロスキンとナノシートの併用療法-

    • Author(s)
      宮崎裕美、 安西一正、 小野聡、木下学、齋藤晃広、武岡真司、齋藤大蔵
    • Organizer
      第39回日本熱傷学会総会・学術集会
    • Place of Presentation
      沖縄
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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