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Oral carcinogenesis by disturbance of squamous differentiation regulated by Notch1

Research Project

Project/Area Number 25462848
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Morphological basic dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Sakamoto Kei  東京医科歯科大学, 医歯(薬)学総合研究科, 講師 (00302886)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords口腔癌 / Notch1 / 扁平上皮癌 / ノックアウトマウス / トランスジェニックマウス / 癌 / 上皮異形成 / ケラチン / 上皮性異形成
Outline of Final Research Achievements

We conducted chemical carcinogenesis experiments on mice by administering a carcinogenic agent by drinking water. Cancers and precancerous lesions like those of human developed in the oral cavity and esophagus. We created epithelial-specific conditional Notch1-knockout mice. These mice exhibited patchy hair loss with hyperplasia of hair follicles. Chemical carcinogenesis experiments revealed increased incidence of esophageal cancer in these mice compared with the wild type littermates. These results indicated that Notch1 plays an important role in development of oroesophageal cancer as a tumor-suppressor gene.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (3 results)

All 2016 2015 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] A facile one-step strategy for the generation of conditional knockout mice to explore the role of Notch1 in oroesophageal tumorigenesis.2016

    • Author(s)
      Mandasari M, Sawangarun W, Katsube K, Kayamori K, Yamaguchi A, Sakamoto K
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 469(3) Issue: 3 Pages: 761-767

    • DOI

      10.1016/j.bbrc.2015.12.006

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Conditional Notch1-knockout Transgenic Mouse Generation by CRISPR/Cas9 Genome Engineering System2015

    • Author(s)
      M Mandasari, W Sawangarun, A Yamaguchi, K Sakamoto
    • Organizer
      IADR South East Asia Division Annual Scientific Meeting
    • Place of Presentation
      Bali, Indonesia
    • Year and Date
      2015-08-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Notch1 expression is downregulated in chemically-induced oral epithelial dysplasia

    • Author(s)
      マシタ マンダサリ、坂本 啓、山口 朗
    • Organizer
      第24回日本臨床口腔病理学会総会・学術大会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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