Oral carcinogenesis by disturbance of squamous differentiation regulated by Notch1
Project/Area Number |
25462848
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Morphological basic dentistry
|
Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
Sakamoto Kei 東京医科歯科大学, 医歯(薬)学総合研究科, 講師 (00302886)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 口腔癌 / Notch1 / 扁平上皮癌 / ノックアウトマウス / トランスジェニックマウス / 癌 / 上皮異形成 / ケラチン / 上皮性異形成 |
Outline of Final Research Achievements |
We conducted chemical carcinogenesis experiments on mice by administering a carcinogenic agent by drinking water. Cancers and precancerous lesions like those of human developed in the oral cavity and esophagus. We created epithelial-specific conditional Notch1-knockout mice. These mice exhibited patchy hair loss with hyperplasia of hair follicles. Chemical carcinogenesis experiments revealed increased incidence of esophageal cancer in these mice compared with the wild type littermates. These results indicated that Notch1 plays an important role in development of oroesophageal cancer as a tumor-suppressor gene.
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Report
(4 results)
Research Products
(3 results)