Proteome analysis of invasion starter molecules in oral squamous cell carcinoma
| Project/Area Number |
25462849
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
Cheng Jun 新潟大学, 医歯学系, 准教授 (40207460)
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| Co-Investigator(Kenkyū-buntansha) |
MARUYAMA Satoshi 新潟大学, 医歯学総合病院, 講師 (30397161)
YAMAZAKI Manabu 新潟大学, 医歯学系, 助教 (10547516)
ABE Tatsuya 新潟大学, 医歯学総合病院, 医員 (70634856)
SAKU Takashi 新潟大学, 医歯学系, 教授 (40145264)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 口腔癌 / 扁平上皮癌 / 浸潤制御 / 実質-間質 / 分子病理学 / 実質ー間質 |
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| Outline of Final Research Achievements |
The molecular mechanism of invasion of oral squamous cell carcinoma still remains unknown. To understand what sort of crosstalk between cancer cells and surrounding non-cancerous epithelial cells or stromal cells, we performed proteome analyses of laser-capture microdissected samples obtained from the interfaces between cancer cell nests and their surrounding non-cancerous epithelium of the oral mucosa or stromal tissues, which were objectively visualized by the aid of immunohistochemistry. As a result, we have determined proteins which were specifically expressed at both cancer and non-cancer sides of the interface zone. They were immunohistochemically identified to be expressed more in cancer or non-cancer sides. Thus, these newly identified molecules are considered to function in regulating squamous cell carcinoma cells to start to invade. It is expected to understand the machinery of cancer invasion when these molecules are investigated more in detail.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] Intramuscular keratocyst as a soft tissue counterpart of keratocystic odontogenic tumor: differential diagnosis by immunohistochemistry.2013
Author(s)
Abe T, Maruyama S, Yamazaki M, Essa A, Babkair H, Mikami T, Shingaki S, Kobayashi T, Hayashi T, Cheng J, Saku T.
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Journal Title
Hum Pathol.
Volume: 45(1)
Issue: 1
Pages: 110-8
DOI
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Peer Reviewed
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[Presentation] 上顎骨腫瘍2015
Author(s)
隅田賢正, 程 クン, 丸山 智, 船山昭典, 小林正治, 西山秀昌, 林 孝文, 朔 敬
Organizer
第26回日本臨床口腔病理学会総会・学術大会
Place of Presentation
北海道大学学術交流会館, 北海道・札幌市
Year and Date
2015-07-29
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[Presentation] 口蓋腫瘍2013
Author(s)
程 クン, 丸山 智, 阿部達也, 山崎 学, 朔 敬
Organizer
第24回日本臨床口腔病理学会総会・学術大会
Place of Presentation
日本大学理工学部１号館 CSTホール、東京都
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