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Proteome analysis of invasion starter molecules in oral squamous cell carcinoma

Research Project

Project/Area Number 25462849
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Morphological basic dentistry
Research InstitutionNiigata University

Principal Investigator

Cheng Jun  新潟大学, 医歯学系, 准教授 (40207460)

Co-Investigator(Kenkyū-buntansha) MARUYAMA Satoshi  新潟大学, 医歯学総合病院, 講師 (30397161)
YAMAZAKI Manabu  新潟大学, 医歯学系, 助教 (10547516)
ABE Tatsuya  新潟大学, 医歯学総合病院, 医員 (70634856)
SAKU Takashi  新潟大学, 医歯学系, 教授 (40145264)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords口腔癌 / 扁平上皮癌 / 浸潤制御 / 実質-間質 / 分子病理学 / 実質ー間質
Outline of Final Research Achievements

The molecular mechanism of invasion of oral squamous cell carcinoma still remains unknown. To understand what sort of crosstalk between cancer cells and surrounding non-cancerous epithelial cells or stromal cells, we performed proteome analyses of laser-capture microdissected samples obtained from the interfaces between cancer cell nests and their surrounding non-cancerous epithelium of the oral mucosa or stromal tissues, which were objectively visualized by the aid of immunohistochemistry. As a result, we have determined proteins which were specifically expressed at both cancer and non-cancer sides of the interface zone. They were immunohistochemically identified to be expressed more in cancer or non-cancer sides. Thus, these newly identified molecules are considered to function in regulating squamous cell carcinoma cells to start to invade. It is expected to understand the machinery of cancer invasion when these molecules are investigated more in detail.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (35 results)

All 2016 2015 2014 2013 Other

All Journal Article (11 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 11 results,  Open Access: 9 results,  Acknowledgement Compliant: 3 results) Presentation (22 results) (of which Int'l Joint Research: 3 results) Remarks (2 results)

  • [Journal Article] Differential immunohistochemical expression profiles of perlecan-binding growth factors in epithelial dysplasia, carcinoma in situ, and squamous cell carcinoma of the oral mucosa.2016

    • Author(s)
      Hasegawa M, Cheng J, Maruyama S, Yamazaki M, Abe T, Babkair H, Saito C, Saku T.
    • Journal Title

      Pathol Res Pract.

      Volume: 212(5) Issue: 5 Pages: 426-436

    • DOI

      10.1016/j.prp.2016.02.016

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tumor-associated macrophages are recruited and differentiated in the neoplastic stroma of oral squamous cell carcinoma.2016

    • Author(s)
      Essa AAM, Yamazaki M, Maruyama S, Abe T, Babkair H, Raghib AM, Megahed EMED, Cheng J, Saku T.
    • Journal Title

      Pathology

      Volume: 48(3) Issue: 3 Pages: 219-227

    • DOI

      10.1016/j.pathol.2016.02.006

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Protease-activated receptor-2 modulates proliferation and invasion of oral squamous cell carcinoma cells.2015

    • Author(s)
      Al-Eryani K, Cheng J, Abe T, Maruyama S, Yamazaki M, Babkair H, Essa A, Saku T
    • Journal Title

      Human Pathology

      Volume: in press Issue: 7 Pages: 991-999

    • DOI

      10.1016/j.humpath.2015.03.003

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Keratin 17 is co-expressed with 14-3-3 sigma in oral carcinoma in situ and squamous cell carcinoma and modulates cell proliferation and size but not cell migration.2015

    • Author(s)
      Mikami T, Maruyama S, Abe T, Kobayashi T, Yamazaki M, Funayama A, Shingaki S, Kobayashi T, Jun C, Saku T.
    • Journal Title

      Virchows Arch.

      Volume: 466(5) Issue: 5 Pages: 559-69

    • DOI

      10.1007/s00428-015-1735-6

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Carcinoma in-situ of the oral mucosa: its pathological diagnostic concept based on the recognition of histological varieties proposed in the JSOP Oral CIS Catalog.2014

    • Author(s)
      The Working Committee for New Histopathological Criteria for Borderline Malignancies of the Oral Mucosa, the Japanese Society of Oral Pathology (JSOP) (including Saku T, Cheng J).
    • Journal Title

      Journal of Oral and Maxillofacial Surgery, Medicine and Pathology

      Volume: in press Issue: 3 Pages: 397-406

    • DOI

      10.1016/j.ajoms.2013.11.003

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Perlecan-enriched intercellular space of junctional epithelium provides primary infrastructure for leucocyte migration through squamous epithelial cells2014

    • Author(s)
      Maruyama S, Itagaki M, Ida-Yonemochi H, Kubota T, Yamazaki M, Abe T, Yoshie H, Cheng J, Saku T
    • Journal Title

      Histochemistry and Cell Biology

      Volume: online published Issue: 3 Pages: 297-305

    • DOI

      10.1007/s00418-014-1198-x

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Three-dimensional visualization of perlecan-rich neoplastic stroma induced concurrently with the invasion of oral squamous cell carcinoma2014

    • Author(s)
      Maruyama S, Shimazu Y, Kudo T, Sato K, Yamazaki M, Abe T, Babkair H, Cheng J, Aoba T, Saku T
    • Journal Title

      Journal of Oral Pathology and Medicine

      Volume: online published Issue: 8 Pages: 627-36

    • DOI

      10.1111/jop.12184

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Keratin pearl degradation in oral squamous cell carcinoma: reciprocal roles of neutrophils and macrophages2014

    • Author(s)
      Essa AAM, Yamazaki M, Maruyama S, Abe T, Babkair H, Cheng J, Saku T
    • Journal Title

      Journal of Oral Pathology and Medicine

      Volume: in press Issue: 10 Pages: 778-84

    • DOI

      10.1111/jop.12197

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] MFG-E8 expression for progression of oral squamous cell carcinoma and for self-clearance of apoptotic cells.2014

    • Author(s)
      Yamazaki M, Maruyama S, Abe T, Essa A, Babkair H, Cheng J, Saku T.
    • Journal Title

      Lab Invest.

      Volume: 94(11) Issue: 11 Pages: 1260-72

    • DOI

      10.1038/labinvest.2014.108

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Podoplanin-mediated cell adhesion through extracellular matrix in oral squamous cell carcinoma2013

    • Author(s)
      Tsuneki M, Yamazaki M, Maruyama S, Cheng J, Saku T
    • Journal Title

      Laboratory Investigation

      Volume: 93 Issue: 8 Pages: 921-932

    • DOI

      10.1038/labinvest.2013.86

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intramuscular keratocyst as a soft tissue counterpart of keratocystic odontogenic tumor: differential diagnosis by immunohistochemistry.2013

    • Author(s)
      Abe T, Maruyama S, Yamazaki M, Essa A, Babkair H, Mikami T, Shingaki S, Kobayashi T, Hayashi T, Cheng J, Saku T.
    • Journal Title

      Hum Pathol.

      Volume: 45(1) Issue: 1 Pages: 110-8

    • DOI

      10.1016/j.humpath.2013.08.011

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Proteomics of the lateral interface of oral squamous cell carcinoma2016

    • Author(s)
      Abe T, Maruyama S, Yamazaki M, Cheng J, Saku T
    • Organizer
      The Global Oral Cancer Forum
    • Place of Presentation
      New York University's Kimmel Center, New York (USA)
    • Year and Date
      2016-03-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] YAP modulates proliferation-differentiation phase switching in oral squamous cell carcinoma and its differentiation represents skin-type orthokeratosis2015

    • Author(s)
      Abe T, Maruyama S, Yamazaki M, Babkair H, Sumita Y, Cheng J, Saku T
    • Organizer
      7th Annual Meeting of Asia Society of Oral & Maxillofacial Pathology
    • Place of Presentation
      Howard International House, Taipei (Taiwan)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 上顎骨腫瘍2015

    • Author(s)
      隅田賢正, 程 クン, 丸山 智, 船山昭典, 小林正治, 西山秀昌, 林 孝文, 朔  敬
    • Organizer
      第26回日本臨床口腔病理学会総会・学術大会
    • Place of Presentation
      北海道大学学術交流会館, 北海道・札幌市
    • Year and Date
      2015-07-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] YAPは口腔扁平上皮癌の増殖―分化の分岐スイッチの役目を担っている:正角化関連分子の動態解析から2015

    • Author(s)
      阿部達也, 丸山 智, 山崎 学, Babkair H, 隅田賢正, 程 クン, 朔  敬
    • Organizer
      第26回日本臨床口腔病理学会総会・学術大会
    • Place of Presentation
      北海道大学学術交流会館, 北海道・札幌市
    • Year and Date
      2015-07-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] GAS6/MERTK axis in oral squamous cell carcinoma: a possible mechanism for apoptotic cancer cell clearance by cancer cells and macrophages2015

    • Author(s)
      山崎 学, 丸山 智, 阿部達也, 程 クン, 朔  敬
    • Organizer
      第26回日本臨床口腔病理学会総会・学術大会
    • Place of Presentation
      北海道大学学術交流会館, 北海道・札幌市
    • Year and Date
      2015-07-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] Tight junction molecules are differentially engaged in the neoplastic process of oral squamous epithelial cells towards squamous cell carcinoma2015

    • Author(s)
      Babkair H, Yamazaki M, Abe T, Maruyama S, Sumita Y, Cheng J, Saku T
    • Organizer
      第26回日本臨床口腔病理学会総会・学術大会
    • Place of Presentation
      北海道大学学術交流会館, 北海道・札幌市
    • Year and Date
      2015-07-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] 口腔扁平上皮癌における皮膚型角化の分化誘導と細胞増殖の調整機構2015

    • Author(s)
      阿部達也, 丸山 智, 山崎 学, Babkair H, 隅田賢正, 程 クン, 朔  敬
    • Organizer
      平成27年度新潟歯学会第1回例会
    • Place of Presentation
      新潟大学歯学部講堂, 新潟県・新潟市
    • Year and Date
      2015-07-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] Tight junction molecules are differentially involved in malignant transformation steps of oral squamous epithelial cells towards squamous cell carcinoma2015

    • Author(s)
      Babkair H, Yamazaki M, Abe T, Maruyama S, Sumita Y, Cheng J, Saku T
    • Organizer
      平成27年度新潟歯学会第1回例会
    • Place of Presentation
      新潟大学歯学部講堂, 新潟県・新潟市
    • Year and Date
      2015-07-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] 口腔扁平上皮癌および正角化型異型上皮における正角化関連分子の動態2015

    • Author(s)
      阿部達也, 丸山 智, 山崎 学, バブカイル ハムザ, 程 クン, 朔  敬
    • Organizer
      第104回日本病理学会総会
    • Place of Presentation
      名古屋国際会議場, 愛知県・名古屋市
    • Year and Date
      2015-04-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] Tight junction molecules are involved in the neoplastic process of oral squamous epithelial cells2015

    • Author(s)
      Babkair H, Yamazaki M, Abe T, Maruyama S, Cheng J, Saku T
    • Organizer
      第104回日本病理学会総会
    • Place of Presentation
      名古屋国際会議場, 愛知県・名古屋市
    • Year and Date
      2015-04-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] Protease-activated receptor-2 modulates proliferation and invasion of oral squamous cell carcinoma cells2015

    • Author(s)
      Cheng J, Al-Eryani K, Abe T, Maruyama S, Yamazaki M, Babkair H, Saku T
    • Organizer
      Asian Oncology Summit 2015
    • Place of Presentation
      Shanghai International Convention Center, Shanghai (China)
    • Year and Date
      2015-04-10
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Histopathological varieties of intraductal papilloma of the oral cavity2015

    • Author(s)
      Cheng J, Wu L, Ahsan S, Maruyama S, Yamazaki M, Abe T, Saku T
    • Organizer
      93rd General Session & Exhibition of the International Association of Dental Research
    • Place of Presentation
      Hynes Convention Center, Boston, USA
    • Year and Date
      2015-03-09 – 2015-03-14
    • Related Report
      2014 Research-status Report
  • [Presentation] 頬粘膜腫瘍2014

    • Author(s)
      Hamzah Babkair ,程 クン, 阿部達也,丸山 智,山崎 学,朔  敬
    • Organizer
      第25回日本臨床口腔病理学会総会・学術大会
    • Place of Presentation
      新潟日報メデアシップ, 新潟市, 日本
    • Year and Date
      2014-08-27 – 2014-08-29
    • Related Report
      2014 Research-status Report
  • [Presentation] 扁平上皮癌シーケンスにおける正角化関連分子の発現動態2014

    • Author(s)
      阿部達也, 丸山 智, Essa Ahmed, Babkair Hamzah, 山崎 学, 程 クン, 朔   敬
    • Organizer
      第103回日本病理学会総会
    • Place of Presentation
      広島国際会議場, 広島市, 日本
    • Year and Date
      2014-04-24 – 2014-04-26
    • Related Report
      2014 Research-status Report
  • [Presentation] Tight junction molecules claudin 1 and zonula ocludnes 1, in oral sqamous cell caricinoma.2014

    • Author(s)
      Babkair Hamzah, 山崎 学, 阿部達也, Essa Ahmed, 丸山 智, 程 クン, 朔   敬
    • Organizer
      第103回日本病理学会総会
    • Place of Presentation
      広島国際会議場, 広島市, 日本
    • Year and Date
      2014-04-24 – 2014-04-26
    • Related Report
      2014 Research-status Report
  • [Presentation] Connexin 43 and podoplanin as novel myoepithelial cell markers in salivary gland tumors2014

    • Author(s)
      Essa Ahmed, 常木雅之, 山崎 学, 丸山 智, 阿部達也, Babkair Hamzah, 程 クン, 朔   敬
    • Organizer
      第103回日本病理学会総会
    • Place of Presentation
      広島国際会議場, 広島市, 日本
    • Year and Date
      2014-04-24 – 2014-04-26
    • Related Report
      2014 Research-status Report
  • [Presentation] 口腔扁平上皮癌の側方進展界面における細胞死2013

    • Author(s)
      阿部達也,丸山 智,Essa Ahmed, Babkair Hamzah, 山崎 学, 程 クン, 朔  敬
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      ロイトン札幌、札幌市
    • Related Report
      2013 Research-status Report
  • [Presentation] MFG-E8は口腔扁平上皮癌の進展と死細胞貪食を促進する2013

    • Author(s)
      山崎 学, 程 クン, 丸山 智,阿部達也,朔  敬
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      ロイトン札幌、札幌市
    • Related Report
      2013 Research-status Report
  • [Presentation] Stromal macrophages in oral squamous cell carcinoma2013

    • Author(s)
      Essa Ahmed, 山崎 学, 丸山 智,阿部達也,Babkair Hamzah, 程 クン, 朔  敬
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      ロイトン札幌、札幌市
    • Related Report
      2013 Research-status Report
  • [Presentation] 口蓋腫瘍2013

    • Author(s)
      程 クン, 丸山 智, 阿部達也, 山崎 学, 朔  敬
    • Organizer
      第24回日本臨床口腔病理学会総会・学術大会
    • Place of Presentation
      日本大学理工学部1号館 CSTホール、東京都
    • Related Report
      2013 Research-status Report
  • [Presentation] Connexin, a gap junction molecule, in oral carcinoma in-situ and squamous cell carcinoma2013

    • Author(s)
      Essa AA, Yamazaki M, Maruyama S, Abe T, Cheng J, Saku T
    • Organizer
      第24回日本臨床口腔病理学会総会・学術大会
    • Place of Presentation
      日本大学理工学部1号館 CSTホール、東京都
    • Related Report
      2013 Research-status Report
  • [Presentation] Tight junction molecules in oral carcinoma in-situ and squamous cell carcinoma2013

    • Author(s)
      Babkair H, Cheng J, Maruyama S, Yamazaki M, Abe T, Essa AA, Saku T
    • Organizer
      第24回日本臨床口腔病理学会総会・学術大会
    • Place of Presentation
      日本大学理工学部1号館 CSTホール、東京都
    • Related Report
      2013 Research-status Report
  • [Remarks] 新潟大学大学院医歯学総合研究科口腔病理学分野 業績

    • URL

      http://www.dent.niigata-u.ac.jp/patho/publications/2015.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 新潟大学大学院医歯学総合研究科口腔病理学分野 - 業績

    • URL

      http://www.dent.niigata-u.ac.jp/patho/publications/index.html

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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