| Project/Area Number |
25462854
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKATA TAKASHI 広島大学, 医歯薬保健学研究院(歯), 教授 (10154783)
MIYAUCHI MUTSUMI 広島大学, 医歯薬保健学研究院(歯), 准教授 (50169265)
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| Co-Investigator(Renkei-kenkyūsha) |
OKA HIROKO 広島大学, 医歯薬保健学研究院(歯), 特任講師 (60452588)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | F-spondin / 骨芽細胞 / IL-6 / 抗炎症作用 / ペプチド / 骨吸収 / 炎症性サイトカイン / 歯槽骨吸収 / トランスジェニックマウス |
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| Outline of Final Research Achievements |
In cementblast forming hard tissue as osteoblast, F-spondin not only promotes calcification but also inhibits IL-6 expression and PGE2 production stimulated by LPS, and it suppresses osteoclast differentiation. In this study, we examined effects of F-spondin on the anti-inflammatory reaction to osteoblast and the inhibition of alveolar bone resorption. In osteoblasts, F-spondin suppressed IL-6 expression in vitro study. In vivo study, the alveoral bone resorption caused by Inflammation was suppressed in the F-spondin overexpressing transgenic mice, but it was difficult to control the periodontitis by use of F-spondin peptide in vivo study.
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