Study on pathological progression mechanisms of non-alcoholic steatohepatitis caused by odontogenic infection of periodontal pathogen
| Project/Area Number |
25462855
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
Miyauchi Mutsumi 広島大学, 医歯薬保健学研究院(歯), 准教授 (50169265)
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| Co-Investigator(Kenkyū-buntansha) |
Furusho Hisako 広島大学, 医歯薬保健学研究院, 助教 (00634461)
Takata Takashi 広島大学, 医歯薬保健学研究院, 教授 (10154783)
Inubushi Toshihiro 広島大学, 医歯薬保健学研究院, 助教 (30550941)
Hyogo Hideyuki 広島大学, 病院(医), 病院助教 (40397930)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 歯性感染 / Porphyromonas gingivalis / Galectin-3 / 非アルコール性脂肪性肝炎 / 線維化 / 肝星細胞 / LPS / TLR2 / TGFβ / 全身疾患 / NASH / 歯周病 / 肝線維化 / 肝癌 / porphyromonas gingivalis / 肝障害 |
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| Outline of Final Research Achievements |
Non-alcoholic steatohepatitis (NASH) has the potential to progress to cirrhosis and hepatocellular carcinoma. Effective therapy has still not been established. In the present study, exacerbation mechanisms of inflammation and fibrosis caused by P.gingivalis (Pg)-odontogenic infection were examined. Upregulation of TLR2 in steatotic hepatocytes (HEP) and increase of macrophages possessing TLR2 played important roles in exacerbation of inflammation through activating TLR2 pathway by Pg-LPS. On the other hand, TGFb1, which was produced by HEP/hepatic stellate cells (HSC) with Pg-infection, promoted liver fibrosis by activating HSC. Detection of Pg in liver from NASH patients were related with high serum level of hyaluronic acid (a serum maker for liver fibrosis) and advanced fibrosis. Therefore, preventing and/or eliminating P.g. infection by dental therapy may have a beneficial impact on management of NASH.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] 9. Dental infection of Porphyromonas gingivalis exacerbates high fat diet-induced steatohepatitis in mice.2013
Author(s)
FurushoH,Miyauchi M,Hyogo H,Inubushi T,Ao M,Ouhara K,Hisatune J,Kurihara H,Sugai M,Hayes CN,Nakahara T,Akikata H,Takahashi S,Chayama K,Takata T
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Journal Title
J Gastroenterol.
Volume: 48(11)
Pages: 1259-70
Related Report
Peer Reviewed
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