Elucidation of the pathogenesis pain mechanism in the trigeminal nerve area with a focus on Toll-like receptor

Research Project

Project/Area Number	25462856
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Morphological basic dentistry
Research Institution	Hiroshima University
Principal Investigator	Watanabe Mineo 広島大学, 医歯薬保健学研究院, 助教 (80325183)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000) Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	口腔解剖学 / 病態痛
Outline of Final Research Achievements	Pathogenic mechanism of extra-territorial facial pain induced by the mental nerve transection were clarified by focusing on Toll-like receptor 4 (TLR4), inflammatory cytokines and intracellular signaling system. In addition, it was also studied bovine lactoferrin application to the extra-territorial facial pain. IL-18 induction via TLR4-derived p38 MAPK signaling pathways in microglia might play an important role in mental nerve transection-induced extra-territorial pain. Further, bovine lactoferrin suppresses the production of the phosphorylation of p38 MAPK and IL-18, and may exert an analgesic effect.

Report

(4 results)