| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
The periodontal pathogen Porphyromonas gingivalis has approximately 30 proteins (called CTD proteins) that contain a conserved C-terminal domain. We have reported that CTD proteins are secreted onto the cell surface via the Type IX secretion system, and some of CTD proteins are anchored on the cell surface by binding to A-LPS. However, the mechanism of A-LPS biosynthesis remains to be determined.
In this study, we found that WzzP, Wzx, WbaP, PGN_0002 are involved in the A-LPS biosynthesis.
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