Development of a logic covariate model for prognostic prediction of oral squamous cell carcinoma

• Project/Area Number: 25462865
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: Nagasaki University
• Principal Investigator: SEKI Sachiko 長崎大学, 医歯薬学総合研究科(歯学系), 客員研究員 (90447491)
• Co-Investigator(Kenkyū-buntansha): Ikeda Tohru 長崎大学, 医歯薬学総合研究科(歯学系), 教授 (00211029) ; Matsuura Masaaki 帝京大学, 公衆衛生学研究科, 教授 (40173794)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 口腔扁平上皮癌 / 予後予測 / 統計解析 / NK細胞 / リンパ球 / 病理診断 / 炎症反応 / 上皮間葉移行 / podoplanin / EMT

Outline of Final Research Achievements

Statistical analysis has been widely applied to social medicine and clinical medical fields. However, in the field of pathology, the diagnostic data are not always provided for statistical analysis, which should be effective for prognostic prediction of malignant tumors. In this study, Cox regression analysis was performed using data of histopathological analysis for the expression of podoplanin, cadherin and inflammatory reaction, which have been suggested to associate with prognosis or malignancy of oral squamous cell carcinoma. We could produce novel models to predict prognosis of oral squamous cell carcinoma using data for the expression of podoplanin, the expression of cadherin and inflammatory reactions, respectively. These data strongly suggested that information of histopathological analysis was useful to produce models to predict prognosis of oral squamous cell carcinoma in combination with other clinical data.

Research Products

• [Journal Article] Prognostic value of podoplanin expression in oral squamous cell carcinoma - a regression model auxiliary to UICC classification (2014)
  • Author(s): Sachiko Seki, Mutsunori Fujiwara, Masaaki Matsuura, Shuichi Fujita, Hisazumi Ikeda, Masahiro Umeda, Izumi Asahina, Tohru Ikeda
  • Journal Title: Pathology & Oncology Research Volume: 20 Issue: 3 Pages: 521-528
  • DOI: 10.1007/s12253-013-9723-0
  • NAID: 120006986485
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 舌扁平上皮癌における予後関連因子としてのpodoplaninの意義 (2014)
  • Author(s): 関 幸子、藤原 睦憲、藤田 修一、池田 通
  • Organizer: 第103回日本病理学会総会
  • Place of Presentation: 広島国際会議場（広島市）
  • Year and Date: 2014-04-24 – 2014-04-26