Investigation of DNA methylation in the multiple oral squamous cell carcinomas
Project/Area Number |
25462867
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Morphological basic dentistry
|
Research Institution | Kagoshima University |
Principal Investigator |
Shima Kaori 鹿児島大学, 医歯学域歯学系, 助教 (10343526)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 口腔扁平上皮癌 / 多発癌 / メチル化 / エピジェネティクス / 前癌病変 / 領域発がん / Field cancerization / epigenetics / 口腔癌 / DNAメチル化 |
Outline of Final Research Achievements |
We have been investing DNA methylation of the promoter region of tumor suppressor genes in the multiple oral squamous cell carcinomas with the concept of field cancerization. The twenty-seven multiple oral squamous cell carcinomas were picked up from o among the 438 primary oral squamous cell carcinomas from our institutional pathology records. The three cases were suspected radiation for the primary lesion induced second carcinoma at other site.
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Report
(4 results)
Research Products
(1 results)