| Project/Area Number |
25462870
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SETA YUJI 九州歯科大学, 歯学部, 教授 (90291616)
TOYONO TAKASHI 九州歯科大学, 歯学部, 助教 (10311929)
KATAOKA SHINJI 九州歯科大学, 歯学部, 助教 (80364149)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 味蕾 / エストロゲン / 伝達物質 / アロマターゼ / 性ステロイド |
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| Outline of Final Research Achievements |
It has become evident that non-gonadal tissues, such as neurons and glial cells in the brain, are able to synthesize steroid hormone. Recently, we have shown that steroidogenic enzymes expressed in the taste bud cells. However,
the exact function of steroid hormones in the taste organ remains unknown. In this study, we have demonstrated that aromatase knockout mice show reduced response to sweet. And we have shown that localizations and patterns of expression of ERα and GPR30 in mouse taste buds. These results suggest estrogen may play an important role for transduction of taste stimuli.
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