| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Outline of Final Research Achievements |
The morbidity of periodontal disease is reported to be 50% above in population worldwide. Some Non-Fermenting Gram-Negative Rods (NFGNR) may cause periodontal disease, such as Porphyromonas gingivalis.
NFGNR is well known as that utilize peptides as energy and carbon sources instead of carbohydrates. DPPs (Dipeptidyl aminopeptidase) are peptide degradation enzymes that play a key part in intake of peptides.
Bacterial DPPs are divided into two categories (Clan SC S9, Clan PA S46). Interestingly, DPPs of Clan PA S46 are only found in bacteria. Our X-ray crystallographic studies of Pseudomonas mexicana WO24 DAP BII and Porphyromonas gingivalis DPP11 revealed that catalytic mechanism and substrate recognition mechanism. These findings are useful in the development of specific inhibitors for S46 peptidases.
|
