| Project/Area Number |
25462874
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Showa University |
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Principal Investigator |
Yamamoto Go 昭和大学, 歯学部, 兼任講師 (80384189)
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| Co-Investigator(Kenkyū-buntansha) |
MISHIMA Kenji 昭和大学, 歯学部, 教授 (50275343)
KOHNO Yohko 昭和大学, 歯学部, 准教授 (40195681)
IRIE Tarou 昭和大学, 歯学部, 講師 (00317570)
YASUHARA Rika 昭和大学, 歯学部, 助教 (20453649)
TANAKA Junichi 昭和大学, 歯学部, 助教 (40710166)
FUKADA Toshiyuki 徳島文理大学, 薬学部, 教授 (70373363)
SUGIYA Hiroshi 日本大学, 生物資源科学部, 教授 (20050114)
FUKUSHIMA Miwako 昭和大学, 歯学部, 助教 (90548273)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 唾液腺 / 亜鉛輸送体 / ZIP10 / 亜鉛 / 放射線照射 / 再生 / 発生 / トランスポーター / ZIP6 |
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| Outline of Final Research Achievements |
Homeostasis of intracellular zinc level is regulated by zinc transporter (ZIP). We hypothesized that zinc transporter family is inovolved in salivary gland development and regeneration. In the analysis of ZIP6 knockout mouse, there is no morphological difference of salivary glands between knockout mouse and wild one. It is suggested that ZIP6 may participate in water secretion but not in protein secretion. ZIP10 was found to be inhibition of cell death of NS-SV-DC (human normal salivary gland cell lines showing ductal cell phenotype) induced by irradiation. These results may be expected to give important finding for ZIP10 to be a promising target molecule of dry mouth and be of some benefit for renewed medical treatment of saliva secretion disorder by using control of ZIP10 expression.
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